Urinary neopterin concentration and toxicity of radiotherapy in patients with head and neck carcinoma during external beam radiation
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24023355
PII: 33/9/4097
Knihovny.cz E-resources
- Keywords
- Head and neck carcinoma, neopterin, radiotherapy, toxicity,
- MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Head and Neck Neoplasms radiotherapy urine MeSH
- Neopterin urine MeSH
- Radiotherapy adverse effects MeSH
- Aged MeSH
- Carcinoma, Squamous Cell radiotherapy urine MeSH
- Chromatography, High Pressure Liquid MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Neopterin MeSH
AIM: Increased serum or urinary concentrations of neopterin are predictive of poor prognosis in patients with tumors across a spectrum of primary locations. Less information is available about the significance of changes of urinary neopterin concentrations during therapy. The aim of the present study was to examine the association between urinary neopterin and toxicity of radiotherapy. PATIENTS AND METHODS: We analyzed changes of urinary neopterin and toxicity of therapy in 12 patients with head and neck carcinoma during external-beam radiation. Urinary neopterin was determined daily by high-performance liquid chromatography. RESULTS: In addition to a trend for increased neopterin concentrations during radiation therapy, a significant association between changes of neopterin and toxicity and vice versa was observed with a rise of neopterin predicting a later manifestation of toxicity as well as manifestion of toxicity predicting a later rise of neopterin. CONCLUSION: Urinary neopterin is predictive of toxicity in patients with head and neck carcinoma. An association between toxicity and subsequent rise of urinary neopterin concentrations was also observed.
Department of Oncology Palacký University Medical School 1 P Pavlova 6 775 20 Olomouc Czech Republic
Neopterin as a biomarker of immune response in cancer patients
