Determination of pteridines in biological samples with an emphasis on their stability
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24053245
DOI
10.4155/bio.13.194
Knihovny.cz E-resources
- MeSH
- Chromatography, Liquid MeSH
- Spectrometry, Fluorescence MeSH
- Mass Spectrometry MeSH
- Hydrogen-Ion Concentration MeSH
- Humans MeSH
- Molecular Structure MeSH
- Oxidation-Reduction MeSH
- Pteridines analysis blood cerebrospinal fluid chemistry urine MeSH
- Body Fluids chemistry MeSH
- Temperature MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Pteridines MeSH
Pteridines are a group of endogenous heterocyclic compounds whose concentrations in biological fluids may be increased in some disorders, such as infections, autoimmune disorders and cancer. In particular, pteridine concentrations in urine may represent promising noninvasive markers. However, their specificity requires further investigation. Pteridines can occur in three oxidation states with different stability. In order to enable the analysis of the unstable di- and tetra-hydroforms either an oxidation (mainly with iodine) or stabilization by reducing agents is applied. Due to the high polarity of pteridines, many analytical procedures employed ion-pair, ion-exchange or hydrophilic interaction liquid chromatography using mostly fluorescence detection. In the last decade, MS was found to be applicable. The objective of this Review is to show possibilities and different approaches in pteridine analysis in biological samples.
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