Prophylaxis and post-exposure treatment of intoxications caused by nerve agents and organophosphorus pesticides
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24195661
DOI
10.2174/13895575113136660108
PII: MRMC-EPUB-57243
Knihovny.cz E-resources
- MeSH
- Acetylcholinesterase chemistry metabolism MeSH
- Antidotes therapeutic use MeSH
- Butyrylcholinesterase chemistry metabolism MeSH
- Chemical Warfare Agents chemistry toxicity MeSH
- Blood-Brain Barrier metabolism MeSH
- Rats MeSH
- Humans MeSH
- Mice MeSH
- Receptors, Nicotinic metabolism MeSH
- Organophosphorus Compounds chemistry toxicity MeSH
- Poisoning drug therapy etiology MeSH
- Oximes chemistry pharmacokinetics therapeutic use MeSH
- Pesticides chemistry toxicity MeSH
- Cholinesterase Reactivators therapeutic use MeSH
- Receptors, Muscarinic metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Antidotes MeSH
- Butyrylcholinesterase MeSH
- Chemical Warfare Agents MeSH
- Receptors, Nicotinic MeSH
- Organophosphorus Compounds MeSH
- Oximes MeSH
- Pesticides MeSH
- Cholinesterase Reactivators MeSH
- Receptors, Muscarinic MeSH
Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.
References provided by Crossref.org
A-series agent A-234: initial in vitro and in vivo characterization
Novichoks: The Dangerous Fourth Generation of Chemical Weapons
