Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.

Center of Advanced Studies Faculty of Military Health Sciences Trebesska 1575 50001 Hradec Kralove Czech Republic

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