Glucose predictability, blood capillary permeability, and glucose utilization rate in subcutaneous, skeletal muscle, and visceral fat tissues
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
24209913
DOI
10.1016/j.compbiomed.2013.08.008
PII: S0010-4825(13)00223-0
Knihovny.cz E-resources
- Keywords
- Glucose, Skeletal muscle, Subcutaneous tissue, Transport rate, Utilization rate, Visceral fat,
- MeSH
- Glucose analysis metabolism MeSH
- Hypertriglyceridemia MeSH
- Capillary Permeability physiology MeSH
- Muscle, Skeletal metabolism MeSH
- Blood Glucose analysis metabolism MeSH
- Rats MeSH
- Intra-Abdominal Fat metabolism MeSH
- Subcutaneous Fat metabolism MeSH
- Models, Statistical MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Glucose MeSH
- Blood Glucose MeSH
This study suggests an approach for the comparison and evaluation of particular compartments with modest experimental setup costs. A glucose level prediction model was used to evaluate the compartment's glucose transport rate across the blood capillary membrane and the glucose utilization rate by the cells. The glucose levels of the blood, subcutaneous tissue, skeletal muscle tissue, and visceral fat were obtained in experiments conducted on hereditary hypertriglyceridemic rats. After the blood glucose level had undergone a rapid change, the experimenter attempted to reach a steady blood glucose level by manually correcting the glucose infusion rate and maintaining a constant insulin infusion rate. The interstitial fluid glucose levels of subcutaneous tissue, skeletal muscle tissue, and visceral fat were evaluated to determine the reaction delay compared with the change in the blood glucose level, the interstitial fluid glucose level predictability, the blood capillary permeability, the effect of the concentration gradient, and the glucose utilization rate. Based on these data, the glucose transport rate across the capillary membrane and the utilization rate in a particular tissue were determined. The rates obtained were successfully verified against positron emission tomography experiments. The subcutaneous tissue exhibits the lowest and the most predictable glucose utilization rate, whereas the skeletal muscle tissue has the greatest glucose utilization rate. In contrast, the visceral fat is the least predictable and has the shortest reaction delay compared with the change in the blood glucose level. The reaction delays obtained for the subcutaneous tissue and skeletal muscle tissue were found to be approximately equal using a metric based on the time required to reach half of the increase in the interstitial fluid glucose level.
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