Survival and clinical outcomes of children starting renal replacement therapy in the neonatal period
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24499775
DOI
10.1038/ki.2013.561
PII: S0085-2538(15)30264-7
Knihovny.cz E-zdroje
- MeSH
- analýza přežití MeSH
- chronické selhání ledvin etiologie mortalita terapie MeSH
- dialýza ledvin MeSH
- kojenec MeSH
- ledviny patofyziologie MeSH
- lidé MeSH
- náhrada funkce ledvin * škodlivé účinky MeSH
- novorozenec MeSH
- peritoneální dialýza MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- registrace MeSH
- transplantace ledvin MeSH
- výsledek terapie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
End-stage renal disease requiring renal replacement therapy (RRT) during the neonatal period is a very rare condition, and little information is available regarding long-term RRT and outcomes. To gain more information, we performed a collaborative study on patient characteristics and treatment outcomes in children who started RRT as neonates during their first month of life between 2000 and 2011 who were prospectively registered in the ESPN/ERA-EDTA, the IPPN (since 2007), the Japanese registry, or the Australian and New Zealand Dialysis and Transplant (ANZDATA) registry. During the first month of life, 264 patients from 32 countries started RRT and were followed for a median of 29 months (interquartile range 11-60 months). Most neonates (242) started on peritoneal dialysis, 21 started on hemodialysis, and 1 patient with a transplant. The most important causes of renal failure were congenital anomalies of the kidney and urinary tract in 141, cystic kidneys in 35, and cortical necrosis in 30. Within 2 years after the start of RRT, 69 children changed dialysis modality and 53 received a renal transplant. After a median of 7 months, 45 children had died, mainly because of infection, resulting in an estimated 2-year survival of 81%, and 5-year survival of 76%. Growth retardation (63%), anemia (55%), and hypertension (57%) were still major problems after 2 years. Thus, relatively good medium-term patient survival may be achieved with RRT started during the neonatal period, but specific therapeutic challenges continue to exist in this age group.
Bristol Royal Hospital for Children Bristol UK
Center for Pediatrics and Adolescent Medicine University of Heidelberg Heidelberg Germany
Children's Hospital University of Helsinki Helsinki Finland
Children's Mercy Hospital Kansas City Missouri USA
Department for Pediatric Nephrology and Hypertension Medical University of Gdansk Gdansk Poland
ESPN ERA EDTA Registry Academic Medical Center Amsterdam The Netherlands
Istituto Giannina Gaslini Genoa Italy
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