Pancreatic stone protein - a possible biomarker of multiorgan failure and mortality in children sepsis
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, pozorovací studie
PubMed
24594294
DOI
10.1016/j.cyto.2014.01.009
PII: S1043-4666(14)00013-1
Knihovny.cz E-zdroje
- Klíčová slova
- Children, Mortality, Pancreatic stone protein, Regenerating protein 1 alpha, Sepsis,
- MeSH
- biologické markery krev MeSH
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- lithostatin krev MeSH
- mladiství MeSH
- mladý dospělý MeSH
- multiorgánové selhání krev mortalita patologie MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- prognóza MeSH
- prospektivní studie MeSH
- sepse krev mortalita patologie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- Názvy látek
- biologické markery MeSH
- lithostatin MeSH
- REG1A protein, human MeSH Prohlížeč
Pancreatic stone protein (PSP)/regenerating protein 1-alpha (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill pediatric patients is unknown. The aim of this pilot study was to evaluate PSP/reg in children with systemic inflammatory response syndrome or sepsis. Prospective observational study, a five day evaluation period in children 0-19years old with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of PSP/reg were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis. PSP/reg levels did not differ between patients with systemic inflammatory response syndrome and septic condition until organ dysfunction signs were present. PSP/reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with MODS. Patients who died tended to have higher PSP/reg levels.
Citace poskytuje Crossref.org
