Pancreatic stone protein - a possible biomarker of multiorgan failure and mortality in children sepsis
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Observational Study
PubMed
24594294
DOI
10.1016/j.cyto.2014.01.009
PII: S1043-4666(14)00013-1
Knihovny.cz E-resources
- Keywords
- Children, Mortality, Pancreatic stone protein, Regenerating protein 1 alpha, Sepsis,
- MeSH
- Biomarkers blood MeSH
- Child MeSH
- Infant MeSH
- Humans MeSH
- Lithostathine blood MeSH
- Adolescent MeSH
- Young Adult MeSH
- Multiple Organ Failure blood mortality pathology MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Sepsis blood mortality pathology MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Names of Substances
- Biomarkers MeSH
- Lithostathine MeSH
- REG1A protein, human MeSH Browser
Pancreatic stone protein (PSP)/regenerating protein 1-alpha (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill pediatric patients is unknown. The aim of this pilot study was to evaluate PSP/reg in children with systemic inflammatory response syndrome or sepsis. Prospective observational study, a five day evaluation period in children 0-19years old with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of PSP/reg were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis. PSP/reg levels did not differ between patients with systemic inflammatory response syndrome and septic condition until organ dysfunction signs were present. PSP/reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with MODS. Patients who died tended to have higher PSP/reg levels.
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