MTHFR and HFE, but not preproghrelin and LBP, polymorphisms as risk factors for all-cause end-stage renal disease development
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24785111
DOI
10.14712/fb2014060020083
PII: file/5719/FB2014A0011.pdf
Knihovny.cz E-resources
- MeSH
- Kidney Failure, Chronic genetics MeSH
- Genetic Predisposition to Disease genetics MeSH
- Ghrelin genetics MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Membrane Glycoproteins genetics MeSH
- Membrane Proteins genetics MeSH
- Methylenetetrahydrofolate Reductase (NADPH2) genetics MeSH
- Histocompatibility Antigens Class I genetics MeSH
- Hemochromatosis Protein MeSH
- Acute-Phase Proteins genetics MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Carrier Proteins genetics MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ghrelin MeSH
- GHRL protein, human MeSH Browser
- HFE protein, human MeSH Browser
- lipopolysaccharide-binding protein MeSH Browser
- Membrane Glycoproteins MeSH
- Membrane Proteins MeSH
- Methylenetetrahydrofolate Reductase (NADPH2) MeSH
- Histocompatibility Antigens Class I MeSH
- MTHFR protein, human MeSH Browser
- Hemochromatosis Protein MeSH
- Acute-Phase Proteins MeSH
- Carrier Proteins MeSH
End-stage renal disease (ESRD) is a serious health problem worldwide. The high prevalence of cardiovascular diseases and chronic inflammation remains a major cause of morbidity and mortality in haemodialysed patients. Beside some external factors, genetic predisposition both to renal failure and poor prognosis has been assumed. We have collected a total of 1,014 haemodialysed patients and 2,559 unrelated healthy Caucasians. Single-nucleotide polymorphisms (SNPs) in genes for preproghrelin (GHRL), lipopolysaccharide-binding protein (LBP), HFE and MTHFR were genotyped. In the group of patients, significantly more carriers presented the MTHFR T667T (P = 0.002) and HFE Asp63Asp (P = 0.001) and Cys282Cys (P = 0.01) genotypes. The frequencies of individual SNPs within GHRL and LBP genes did not differ between the patients and controls. The trends in genotype frequencies did not differ between the subgroups of patients with different time on haemodialysis. Common variants in MTHFR and HFE could be a risk factor for all-cause ESRD development, but are not predictors for the survival on haemodialysis.
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