The evaluation of prophylactic efficacy of newly developed reversible inhibitors of acetylcholinesterase in soman-poisoned mice - a comparison with commonly used pyridostigmine
Language English Country Great Britain, England Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
24842281
DOI
10.1111/bcpt.12269
Knihovny.cz E-resources
- MeSH
- Antidotes therapeutic use MeSH
- Cholinesterase Inhibitors therapeutic use MeSH
- Lethal Dose 50 MeSH
- Mice MeSH
- Piperazines therapeutic use MeSH
- Pyridostigmine Bromide therapeutic use MeSH
- Soman antagonists & inhibitors poisoning MeSH
- Tacrine analogs & derivatives therapeutic use MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- 7-methoxy-N-(2-(4-(3-methylbenzyl)piperazine-1-yl)ethyl)-1,2,3,4-tetrahydroacridin-9-amine MeSH Browser
- Antidotes MeSH
- Cholinesterase Inhibitors MeSH
- N-(2-(4-(3-bromobenzyl)piperazine-1-yl)ethyl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine MeSH Browser
- N-ethyltacrine MeSH Browser
- N-hexyl-7-methoxytacrine MeSH Browser
- Piperazines MeSH
- Pyridostigmine Bromide MeSH
- Soman MeSH
- Tacrine MeSH
The ability of four newly developed reversible inhibitors of acetylcholinesterase (PC-37, PC-48, JaKo 39, JaKo 40) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was evaluated and compared. No reversible inhibitor of acetylcholinesterase studied was able to decrease the LD50 value of soman in mice. Thus, the pharmacological pre-treatment with pyridostigmine or newly synthesized inhibitors of acetylcholinesterase was not able to significantly protect mice against soman-induced lethal acute toxicity. In addition, neither pyridostigmine nor new reversible inhibitors of acetylcholinesterase was able to increase the efficacy of antidotal treatment (the oxime HI-6 in combination with atropine) of soman-poisoned mice. These findings demonstrate that pharmacological pre-treatment of soman-poisoned mice with tested reversible inhibitors of acetylcholinesterase is not promising.
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