We wish to offer some comments on the article by H. Liu et al. entitled "Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats", published in Molecules in 2012 [1]. [...].

Charles University Prague Faculty of Medicine in Hradec Králové Šimkova 870 500 38 Hradec Králové Czech Republic

Department of Pharmacology and Toxicology Charles University Prague Faculty of Pharmacy in Hradec Králové Heyrovského 1203 500 05 Hradec Králové Czech Republic

Molecules. 2012 Apr 10;17(4):4281-91. doi: 10.3390/molecules17044281. PubMed

See more in PubMed

Liu H., Zhang L., Lu S. Evaluation of antioxidant and immunity activities of quercetin in isoproterenol-treated rats. Molecules. 2012;17:4281–4291. doi: 10.3390/molecules17044281. PubMed DOI PMC

Beinfield W.H., Lehr D. QRS-T variations in the rat electrocardiogram. Am. J. Physiol. 1968;214:197–204. PubMed

Cialdella-Kam L., Nieman D.C., Sha W., Meaney M.P., Knab A.M., Shanely R.A. Dose-response to 3 months of quercetin-containing supplements on metabolite and quercetin conjugate profile in adults. Br. J. Nutr. 2012:1–11. PubMed

Ader P., Wessmann A., Wolffram S. Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radic. Biol. Med. 2000;28:1056–1067. doi: 10.1016/S0891-5849(00)00195-7. PubMed DOI

De Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C. Tissue distribution of quercetin in rats and pigs. J. Nutr. 2005;135:1718–1725. PubMed

Egert S., Wolffram S., Bosy-Westphal A., Boesch-Saadatmandi C., Wagner A.E., Frank J., Rimbach G., Mueller M.J. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 2008;138:1615–1621. PubMed

Comprehensive review of cardiovascular toxicity of drugs and related agents

Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress