Retinal vein occlusion (RVO) is a major cause of vision loss. Of the two main types of RVO, branch retinal vein occlusion (BRVO) is 4 to 6 times more prevalent than central retinal vein occlusion (CRVO). A basic risk factor for RVO is advancing age. Further risk factors include systemic conditions like hypertension, arteriosclerosis, diabetes mellitus, hyperlipidemia, vascular cerebral stroke, blood hyperviscosity, and thrombophilia. A strong risk factor for RVO is the metabolic syndrome (hypertension, diabetes mellitus, and hyperlipidemia). Individuals with end-organ damage caused by diabetes mellitus and hypertension have greatly increased risk for RVO. Socioeconomic status seems to be a risk factor too. American blacks are more often diagnosed with RVO than non-Hispanic whites. Females are, according to some studies, at lower risk than men. The role of thrombophilic risk factors in RVO is still controversial. Congenital thrombophilic diseases like factor V Leiden mutation, hyperhomocysteinemia and anticardiolipin antibodies increase the risk of RVO. Cigarette smoking also increases the risk of RVO as do systemic inflammatory conditions like vasculitis and Behcet disease. Ophthalmic risk factors for RVO are ocular hypertension and glaucoma, higher ocular perfusion pressure, and changes in the retinal arteries.

University Eye Clinic Masaryk University Brno and University Hospital Brno Jihlavska 20 625 00 Brno Czech Republic

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Hayreh SS, Zimmerman MB, Podhajsky P. Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics. American Journal of Ophthalmology. 1994;117(4):429–441. PubMed

Hayreh SS, Zimmerman MB. Branch retinal vein occlusion: natural history of visual outcome. JAMA Ophthalmology. 2014;132(1):13–22. PubMed

Hayreh SS. Prevalent misconceptions about acute retinal vascular occlusive disorders. Progress in Retinal and Eye Research. 2005;24(4):493–519. PubMed

Rogers S, McIntosh RL, Cheung N, et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313.e1–319.e1. PubMed PMC

Rehak M, Wiedemann P. Retinal vein thrombosis: pathogenesis and management. Journal of Thrombosis and Haemostasis. 2010;8(9):1886–1894. PubMed

Zhou JQ, Xu L, Wang S, et al. The 10-year incidence and risk factors of retinal vein occlusion: the Beijing eye study. Ophthalmology. 2013;120(4):803–808. PubMed

Yau JWY, Lee P, Wong TY, Best J, Jenkins A. Retinal vein occlusion: an approach to diagnosis, systemic risk factors and management. Internal Medicine Journal. 2008;38(12):904–910. PubMed

Mohamed Q, McIntosh RL, Saw SM, Wong TY. Interventions for central retinal vein occlusion. An evidence-based systematic review. Ophthalmology. 2007;114(3):507–519. PubMed

Ehlers JP, Fekrat S. Retinal vein occlusion: beyond the acute event. Survey of Ophthalmology. 2011;56(4):281–299. PubMed

Klein R, Klein BEK, Moss SE, et al. The epidemiology of retinal vein occlusion: the beaver dam eye study. Transactions of the American Ophthalmological Society. 2000;98:133–143. PubMed PMC

Eye Disease Case-Control Study Group. Risk factors for central retinal vein occlusion. Archives of Ophthalmology. 1996;114(5):545–554. PubMed

Mitchell P, Smith W, Chang A. Prevalence and associations of retinal vein occlusion in Australia: the blue mountains eye study. Archives of Ophthalmology. 1996;114(10):1243–1247. PubMed

Schmidt D. Comorbidities in combined retinal artery and vein occlusions. European Journal of Medical Research. 2013;18, article 27 PubMed PMC

Stem MS, Talwar N, Comer GM, Stein JD. A longitudinal analysis of risk factors associated with central retinal vein occlusion. Ophthalmology. 2013;120(2):362–370. PubMed PMC

Jaulim A, Ahmed B, Khanam T, Chatziralli IP. Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina. 2013;33(5):901–910. PubMed

Chatziralli IP, Jaulim A, Peponis VG, Mitropoulos PG, Moschos MM. Branch retinal vein occlusion: treatment modalities: an update of the literature. Seminars in Ophthalmology. 2014;29(2):85–107. PubMed

Rehak J, Rehak M. Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Current Eye Research. 2008;33(2):111–131. PubMed PMC

Jefferies P, Clemett RS, Day T. An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions. Australian and New Zealand Journal of Ophthalmology. 1993;21(4):213–217. PubMed

Christoffersen NLB, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology. 1999;106(11):2054–2062. PubMed

O’Mahoney PRA, Wong DT, Ray JG. Retinal vein occlusion and traditional risk factors for atherosclerosis. Archives of Ophthalmology. 2008;126(5):692–699. PubMed

Lam HD, Lahey JM, Kearney JJ, Ng RR, Lehmer JM, Tanaka SC. Young patients with branch retinal vein occlusion: a review of 60 cases. Retina. 2010;30(9):1520–1523. PubMed

Ring CP, Pearson TC, Sanders MD, Wetherley Mein G. Viscosity and retinal vein thrombosis. British Journal of Ophthalmology. 1976;60(6):397–410. PubMed PMC

Janssen MCH, den Heijer M, Cruysberg JRM, Wollersheim H, Bredie SJH. Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors. Thrombosis and Haemostasis. 2005;93(6):1021–1026. PubMed

Fong ACO, Schatz H. Central retinal vein occlusion in young adults. Survey of Ophthalmology. 1993;37(6):393–417. PubMed

Kuhli-Hattenbach C, Scharrer I, Lüchtenberg M, Hattenbach LO. Selective thrombophilia screening of young patients with retinal vein occlusion. Klinische Monatsblatter für Augenheilkunde. 2009;226(9):768–773. PubMed

Rehak M, Rehak J, Müller M, et al. The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors. Case-control study and meta-analysis. Thrombosis and Haemostasis. 2008;99(5):925–929. PubMed

Sofi F, Marcucci R, Bolli P, et al. Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels. Atherosclerosis. 2008;198(1):223–227. PubMed

Glueck CJ, Wang P, Hutchins R, Petersen MR, Golnik K. Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions. Clinical and Applied Thrombosis/Hemostasis. 2008;14(3):286–294. PubMed

Rehak M, Müller M, Scholz M, Wiercinska J, Niederwieser D, Wiedemann P. Antiphospholipidsyndrom und retinale venöse Verschlüsse. Der Ophthalmologe. 106(5):427–434. PubMed

Janssen MCH, den Heijer M, Cruysberg JRM, Wollersheim H, Bredie SJH. Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors. Thrombosis and Haemostasis. 2005;93(6):1021–1026. PubMed

di Capua M, Coppola A, Albisinni R, et al. Cardiovascular risk factors and outcome in patients with retinal vein occlusion. Journal of Thrombosis and Thrombolysis. 2010;30(1):16–22. PubMed

Hypertension, hyperlipidaemia and thrombophilia as the most common risk factors for retinal vein occlusion in patients under 50 years