Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25181677
DOI
10.1016/j.bioorg.2014.08.001
PII: S0045-2068(14)00066-2
Knihovny.cz E-zdroje
- Klíčová slova
- Cytotoxic activity, Liliaceae, Scilla persica, Scillapersicone, Single-crystal X-ray, Theoretical analysis,
- MeSH
- flavonoidy chemie izolace a purifikace farmakologie MeSH
- fytogenní protinádorové látky chemie izolace a purifikace farmakologie MeSH
- krystalografie rentgenová MeSH
- lidé MeSH
- molekulární modely MeSH
- nádorové buněčné linie MeSH
- nádory farmakoterapie MeSH
- rostlinné extrakty chemie MeSH
- Scilla chemie MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- flavonoidy MeSH
- fytogenní protinádorové látky MeSH
- rostlinné extrakty MeSH
In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3',4'-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a=11.7676 (2)Å, b=20.1174 (4)Å, c=7.8645 (9)Å, β=93.544 (2)°, V=1858.23 (7)Å(3), monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
Department of Animal Biology School of Natural Sciences University of Tabriz Tabriz Iran
Department of Chemistry Faculty of Sciences Golestan University Gorgan 4913815759 Iran
Department of Chemistry Gorgan Branch Islamic Azad University Gorgan Iran
Department of Pharmaceutical Sciences Faculty of Pharmacy Keio University Tokyo Japan
Institute of Physics AS CR v v i Na Slovance 2 182 21 Prague 8 Czech Republic
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