Endocrine disrupting compounds affecting corticosteroid signaling pathways in Czech and Swiss waters: potential impact on fish
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25269596
DOI
10.1021/es502711c
Knihovny.cz E-resources
- MeSH
- Biological Assay methods MeSH
- Water Pollutants, Chemical analysis blood pharmacokinetics toxicity MeSH
- Endocrine Disruptors analysis MeSH
- Adrenal Cortex Hormones metabolism MeSH
- Humans MeSH
- Wastewater analysis MeSH
- Rivers chemistry MeSH
- Fishes blood metabolism MeSH
- Fresh Water analysis chemistry MeSH
- Tandem Mass Spectrometry methods MeSH
- Toxicity Tests methods MeSH
- Chromatography, High Pressure Liquid methods MeSH
- Environment MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Switzerland MeSH
- Names of Substances
- Water Pollutants, Chemical MeSH
- Endocrine Disruptors MeSH
- Adrenal Cortex Hormones MeSH
- Waste Water MeSH
This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 μg/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from
References provided by Crossref.org
