Sequence-based prediction of linear autoepitopes involved in pathogenesis of IPAH and the corresponding organism sources of molecular mimicry
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
25335565
DOI
10.1504/ijbra.2014.065244
PII: 63N21W72757476Q4
Knihovny.cz E-zdroje
- Klíčová slova
- AIDS, APAH, DQPA, IPAH pathogenesis, autoantibody response, autoantigens, autoimmune diseases, bioinformatics, cross–reactivities, dense quasi–pattern sequences, fibrillin, idiopathic pulmonary arterial hypertension, immune tolerance, linear autoepitopes, metalloproteinase, microorganisms, molecular mimicry, organism sources, pathogenic effects, proline, remodelling, sequence based prediction,
- MeSH
- druhová specificita MeSH
- epitopy chemie genetika imunologie MeSH
- familiární plicní arteriální hypertenze genetika imunologie mikrobiologie MeSH
- konzervovaná sekvence MeSH
- lidé MeSH
- molekulární mimikry genetika imunologie MeSH
- molekulární sekvence - údaje MeSH
- sekvence aminokyselin MeSH
- sekvenční analýza proteinů metody MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- epitopy MeSH
We proposed here a sequence-based approach predicting some microorganisms as possible sources of autoantigen-related molecular mimicry concerning Idiopathic Pulmonary Arterial Hypertension (IPAH) and related hypertension mostly accompanying autoimmune diseases and AIDS (APAH). This approach (SPECIES_VALENCE) processes the database occurrences of linear autoepitope-related short Dense Quasi-Pattern Sequences (DQPA) generated based on identities of important autoantigenic sequences. The corresponding enumeration comprises two types of statistical evaluations performed in each of eight proposed models. Based on this enumeration, we selected nine microorganisms, whereas revaluation of the obtained scoring values restricted Pseudomonas aeruginosa, Aspergillus fumigatus and the two co-infecting herpes viruses (Epstein Barr virus and cytomegalovirus) as most favourable. The results are discussed in terms of (a) the validity of increased DQPA occurrence in functionally correlated sequences, (b) the possible mechanisms leading to autoantibody response, (c) selected additional pathogenic effects of predicted microorganisms and (d) possible effects of cross-reactivities and immune tolerance.
Department of Medical Chemistry and Clinical Biochemistry Charles University Prague Czech Republic
Department of Physiology Center for Cardiovascular Research Charles University Prague Czech Republic
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