Sequence-based prediction of linear autoepitopes involved in pathogenesis of IPAH and the corresponding organism sources of molecular mimicry
Language English Country Switzerland Media print
Document type Journal Article
PubMed
25335565
DOI
10.1504/ijbra.2014.065244
PII: 63N21W72757476Q4
Knihovny.cz E-resources
- Keywords
- AIDS, APAH, DQPA, IPAH pathogenesis, autoantibody response, autoantigens, autoimmune diseases, bioinformatics, cross–reactivities, dense quasi–pattern sequences, fibrillin, idiopathic pulmonary arterial hypertension, immune tolerance, linear autoepitopes, metalloproteinase, microorganisms, molecular mimicry, organism sources, pathogenic effects, proline, remodelling, sequence based prediction,
- MeSH
- Species Specificity MeSH
- Epitopes chemistry genetics immunology MeSH
- Familial Primary Pulmonary Hypertension genetics immunology microbiology MeSH
- Conserved Sequence MeSH
- Humans MeSH
- Molecular Mimicry genetics immunology MeSH
- Molecular Sequence Data MeSH
- Amino Acid Sequence MeSH
- Sequence Analysis, Protein methods MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Epitopes MeSH
We proposed here a sequence-based approach predicting some microorganisms as possible sources of autoantigen-related molecular mimicry concerning Idiopathic Pulmonary Arterial Hypertension (IPAH) and related hypertension mostly accompanying autoimmune diseases and AIDS (APAH). This approach (SPECIES_VALENCE) processes the database occurrences of linear autoepitope-related short Dense Quasi-Pattern Sequences (DQPA) generated based on identities of important autoantigenic sequences. The corresponding enumeration comprises two types of statistical evaluations performed in each of eight proposed models. Based on this enumeration, we selected nine microorganisms, whereas revaluation of the obtained scoring values restricted Pseudomonas aeruginosa, Aspergillus fumigatus and the two co-infecting herpes viruses (Epstein Barr virus and cytomegalovirus) as most favourable. The results are discussed in terms of (a) the validity of increased DQPA occurrence in functionally correlated sequences, (b) the possible mechanisms leading to autoantibody response, (c) selected additional pathogenic effects of predicted microorganisms and (d) possible effects of cross-reactivities and immune tolerance.
Department of Medical Chemistry and Clinical Biochemistry Charles University Prague Czech Republic
Department of Physiology Center for Cardiovascular Research Charles University Prague Czech Republic
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