Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25440294
DOI
10.1016/j.envres.2014.08.016
PII: S0013-9351(14)00276-X
Knihovny.cz E-resources
- Keywords
- COPHES, DEMOCOPHES, External exposure data, Human biomonitoring, Interpretation,
- MeSH
- Biomarkers analysis urine MeSH
- Child MeSH
- Adult MeSH
- Data Interpretation, Statistical MeSH
- Cadmium analysis urine MeSH
- Cotinine urine MeSH
- Smoking legislation & jurisprudence urine MeSH
- Environmental Pollutants analysis urine MeSH
- Humans MeSH
- Urban Population statistics & numerical data MeSH
- Environmental Monitoring methods statistics & numerical data MeSH
- Seafood statistics & numerical data MeSH
- Surveys and Questionnaires standards MeSH
- Mercury analysis urine MeSH
- Rural Population statistics & numerical data MeSH
- Government Regulation MeSH
- Hair chemistry MeSH
- Environmental Exposure analysis statistics & numerical data MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
- Names of Substances
- Biomarkers MeSH
- Cadmium MeSH
- Cotinine MeSH
- Environmental Pollutants MeSH
- Mercury MeSH
In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.
Centre de Recherche Public Gabriel Lippmann Luxembourg
Environmental Health Center Romania
Environmental Health Sciences International The Netherlands
Faculdade de Medicina de Lisboa Portugal
Federal Environment Agency Germany
Federal Office of Public Health Switzerland
FPS Health Food Chain Safety and Environment Belgium
Health Service Executive Ireland
Instituto de Salud Carlos 3 Spain
Jožef Stefan Institute Slovenia
Laboratoire Nationale de Santé Luxembourg
Larnaca General Hospital Ministry of Health Cyprus
National Institute of Environmental Health Hungary
National Institute of Public Health Czech Republic
Nofer Institute of Occupational Medicine Poland
Public Health England United Kingdom
State General Laboratory Ministry of Health Cyprus
University College Dublin Ireland
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