Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25456460
DOI
10.1016/j.jns.2014.10.002
PII: S0022-510X(14)00655-8
Knihovny.cz E-zdroje
- Klíčová slova
- Clinically isolated syndrom, Cognition, Gray matter, Learning effect, MRI, Multiple sclerosis,
- MeSH
- atrofie MeSH
- časové faktory MeSH
- dospělí MeSH
- interferon beta 1a MeSH
- interferon beta terapeutické užití MeSH
- kognice * účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie * MeSH
- mozek patologie MeSH
- následné studie MeSH
- neuropsychologické testy MeSH
- progrese nemoci MeSH
- prospektivní studie MeSH
- roztroušená skleróza farmakoterapie patologie MeSH
- šedá hmota patologie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- interferon beta 1a MeSH
- interferon beta MeSH
BACKGROUND: Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. OBJECTIVES: The aim of this study is to determine if change in brain MRI metrics predicts evolution of PASAT in high functioning clinically isolated syndrome (CIS) patients on disease-modifying treatment (DMT). METHODS: This prospective 48-month observational study examined 128 CIS patients treated with 30 μg of intramuscular interferon beta-1a once a week. The correlation between PASAT and MRI measures was assessed at baseline, at 6 months and then annually over the 48-month follow up. Linear mixed model analysis adjusted for age, gender, education and DMT was used to model the temporal association between MRI measures and PASAT performance. RESULTS: MRI revealed 2.5% gray matter (GM) volume loss and 4.3 point increase in PASAT score over 48 months. MS patients evidenced significantly greater PASAT score absolute change, had lower loss of GM volume (p=.008) but not significant change in cortical (p=.061), white matter (p=.086) or whole brain volumes (p=.879). CONCLUSIONS: The present study reveals a significant relationship between higher PASAT learning effect and less GM atrophy in CIS patients on DMT. These findings suggest that change in PASAT associated more with GM than WM pathology, and that treatment strategies oriented toward GM volume preservation may play an important role in prevention of cognitive deterioration in CIS patients.
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