Developmental patterns of postictal refractoriness and potentiation akin to cortical stimulation
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
25470530
DOI
10.1111/epi.12870
Knihovny.cz E-resources
- Keywords
- Cortical afterdischarges, Postnatal development, Rat, Refractoriness,
- MeSH
- Electric Stimulation MeSH
- Electroencephalography MeSH
- Electrodes, Implanted MeSH
- Rats MeSH
- Limbic System growth & development physiology MeSH
- Cerebral Cortex growth & development physiology MeSH
- Animals, Newborn MeSH
- Refractory Period, Electrophysiological physiology MeSH
- Seizures physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old with implanted electrodes formed the experimental groups. Stimulation was performed by 15-s series of 1-msec pulses with suprathreshold intensity and frequency of 8 Hz. Paired stimulation of the cerebral cortex in 12-day-old rats elicited the second afterdischarge, even if the 30-s interval was used. Refractoriness started to appear in the third postnatal week and developed progressively so that 25-day-old rats did not differ from adult animals, that is, an interval longer than 1 min was necessary for elicitation of the second seizure.
References provided by Crossref.org
Seizures elicited by transcorneal 6 Hz stimulation in developing rats
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats
