Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25617711
DOI
10.1016/j.apradiso.2015.01.005
PII: S0969-8043(15)00006-8
Knihovny.cz E-resources
- Keywords
- Brachytherapy, Poly(N-vinylcaprolactam), Thermosensitive polymer, Tumor,
- MeSH
- Biocompatible Materials chemistry MeSH
- Brachytherapy methods MeSH
- Caprolactam analogs & derivatives chemistry MeSH
- Humans MeSH
- Methacrylates chemistry MeSH
- Neoplasms radiotherapy MeSH
- Polymers chemistry MeSH
- Iodine Radioisotopes therapeutic use MeSH
- Solubility MeSH
- Temperature MeSH
- Materials Testing MeSH
- Tyrosine analogs & derivatives chemistry MeSH
- Water MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Caprolactam MeSH
- Methacrylates MeSH
- N-methacryloyl tyrosinamide MeSH Browser
- poly-N-vinylcaprolactam MeSH Browser
- Polymers MeSH
- Iodine Radioisotopes MeSH
- Tyrosine MeSH
- Water MeSH
Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with (125)I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33-35°C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors.
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