Silver release and antimicrobial properties of PMMA films doped with silver ions, nano-particles and complexes
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25686981
DOI
10.1016/j.msec.2015.01.022
PII: S0928-4931(15)00032-6
Knihovny.cz E-resources
- Keywords
- Antimicrobial properties, Doped polymer, Silver helical complex, Silver nanoparticles,
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Cysteine metabolism MeSH
- Escherichia coli drug effects MeSH
- Imidazoles chemistry pharmacology MeSH
- Ions chemistry MeSH
- Microbial Sensitivity Tests methods MeSH
- Nanoparticles chemistry MeSH
- Polymers chemistry MeSH
- Polymethyl Methacrylate chemistry pharmacology MeSH
- Silver Compounds chemistry pharmacology MeSH
- Staphylococcus epidermidis drug effects MeSH
- Silver chemistry pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Cysteine MeSH
- imidazole MeSH Browser
- Imidazoles MeSH
- Ions MeSH
- Polymers MeSH
- Polymethyl Methacrylate MeSH
- Silver Compounds MeSH
- Silver MeSH
Materials prepared on the base of bioactive silver compounds have become more and more popular due to low microbial resistance to silver. In the present work, the efficiency of polymethylmethacrylate (PMMA) thin films doped with silver ions, nanoparticles and silver-imidazole polymer complex was studied by a combination of AAS, XPS and AFM techniques. The biological activities of the proposed materials were discussed in view of the rate of silver releasing from the polymer matrix. Concentrations of Ag active form were estimated by its ability to interact with l-cysteine using electronic circular dichroism spectroscopy. Rates of the released silver were compared with the biological activity in dependence on the form of embedded silver. Antimicrobial properties of doped polymer films were studied using two bacterial strains: Staphylococcus epidermidis and Escherichia coli. It was found that PMMA films doped with Ag(+) had greater activity than those doped with nanoparticles and silver-imidazole polymeric complexes. However, the antimicrobial efficiency of Ag(+) doped films was only short-term. Contrary, the antimicrobial activity of silver-imidazole/PMMA films increased in time of sample soaking.
Department of Analytical Chemistry Institute of Chemical Technology Prague Czech Republic
Department of Biochemistry and Microbiology Institute of Chemical Technology Prague Czech Republic
Department of Solid State Engineering Institute of Chemical Technology Prague Czech Republic
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