Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25907329
DOI
10.1016/j.autneu.2015.04.001
PII: S1566-0702(15)00037-5
Knihovny.cz E-resources
- Keywords
- Autonomic cardiac regulation, Desaturation, Simulated altitude, Sympathovagal balance, Vagal activity,
- MeSH
- Arteries metabolism MeSH
- Adult MeSH
- Hypoxia physiopathology MeSH
- Oxygen blood MeSH
- Humans MeSH
- Vagus Nerve physiopathology MeSH
- Heart Rate physiology MeSH
- Sympathetic Nervous System physiopathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Oxygen MeSH
The primary purpose of this study was to assess the response of autonomic cardiac activity and changes in the arterial oxygen saturation (SpO2) during normobaric hypoxia and subsequent recovery. Heart rate variability (HRV) and SpO2 were monitored in a supine position during hypoxia (FiO2=9.6%) for 10min, and normoxic recovery in 29 subjects. Spectral analysis of HRV quantified the autonomic cardiac activity by means of low frequency (LF) (0.05-0.15Hz) and high frequency (HF) (0.15-0.50Hz) power transformed by natural logarithm (Ln). Based on the SpO2 response to hypoxia, the subjects were divided into Resistant (RG, SpO2=80.8±7.0%) or Sensitive (SG, SpO2=67.2±2.9%) group. The SpO2 and vagal activity (LnHF) significantly decreased during hypoxia in both groups. A withdrawal in vagal activity was significantly greater in SG compared to RG. Moreover, only in SG, a relative increase in sympathetic modulation (Ln LF/HF) during hypoxia occurred. Correlations (r=-0.461, and r=0.595, both P<0.05) between ΔSpO2 (delta) and ΔLn LF/HF, and ΔLnHF were found. Based on results, it seems that SpO2 level could be an important factor that influences the autonomic cardiac response in hypoxia.
References provided by Crossref.org
Acute Severe Heart Failure Reduces Heart Rate Variability: An Experimental Study in a Porcine Model