Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe
Language English Country Germany Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Radiotherapy, Adjuvant MeSH
- Child MeSH
- Sarcoma, Ewing mortality therapy MeSH
- Clinical Trials as Topic MeSH
- Combined Modality Therapy MeSH
- Cooperative Behavior * MeSH
- Humans MeSH
- Interdisciplinary Communication * MeSH
- Survival Rate MeSH
- Bone Neoplasms mortality therapy MeSH
- Soft Tissue Neoplasms mortality therapy MeSH
- Neoadjuvant Therapy MeSH
- Osteotomy MeSH
- Disease Progression MeSH
- Antineoplastic Combined Chemotherapy Protocols MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.
Alder Hey Children's National Health Service Foundation Trust Liverpool UK
Department of Clinical Radiology University Hospital Muenster Muenster Germany
Department of Nuclear Medicine University of Münster Münster Germany
Department of Orthopedic Surgery University Hospital Muenster Muenster Germany
Department of Pediatrics Klinikum rechts der Isar Technische Universität München Munich Germany
Department of Radiation Therapy University of Erlangen Erlangen Germany
Department of Radiotherapy and Radiation Oncology Saarland University Medical Center Homburg Germany
Department of Radiotherapy University Hospital Muenster Muenster Germany
Department Osnabrueck Center for Radiotherapy Rheine Osnabrueck Osnabrueck Germany
Emma Children Hospital AMC University of Amsterdam Amsterdam the Netherlands
Gustave Roussy Institute Villejuif France
Inserm U830 Laboratory of Genetics and Biology of Cancers Institut Curie Paris France
Institute of Biostatistics and Clinical Research University of Muenster Muenster Germany
Institute of Experimental Musculoskeletal Medicine University Hospital Muenster Muenster Germany
NIHR University College London Hospitals Biomedical Research Centre London UK
Pediatric Hematology and Oncology Muenster University Children's Hospital Muenster Germany
Royal Victoria Infirmary Newcastle United Kingdom
Skåne University Hospital Lund University Lund Sweden
Université Paris Sud Le Kremlin Bicêtre and Gustave Roussy Institute Villejuif France
Vestische Kinder und Jugendklinik Datteln Witten Herdecke University Datteln Germany
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