Biologická dostupnost léčiva a možnosti jejího ovlivňování
[Bioavailability and factors influencing its rate]
Jazyk čeština Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
26084643
PII: 52403
- Klíčová slova
- bioavailability drug solubility poorly soluble drugs factors influencing bioavailability.,
- MeSH
- aplikace orální MeSH
- biologická dostupnost * MeSH
- léčivé přípravky aplikace a dávkování MeSH
- lidé MeSH
- rozpustnost MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- léčivé přípravky MeSH
Bioavailability can be defined as the rate and range of active ingredient absorption, when it becomes available in the systemic circulation or at the desired site of drug action, respectively. Drug bioavailability after oral administration is affected by anumber of different factors, including physicochemical properties of the drug, physiological aspects, the type of dosage form, food intake, biorhythms, and intra- and interindividual variability of the human population. This article is the first from the series dealing with the bioavailability and methods leading to its improvement. The aim of the present paper is to provide an overview of aspects influencing the rate of bioavailability after oral administration of the active ingredient. Subsequentarticles will provide detailed descriptions of methods used for dug bioavailability improvement, which are here only summarized.
Efficacy of the intranasal application of azaperone for sedation in weaned piglets