Sampling times influence the estimate of parameters in the Weibull dissolution model
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26215461
DOI
10.1016/j.ejps.2015.07.015
PII: S0928-0987(15)00348-6
Knihovny.cz E-resources
- Keywords
- Dissolution, Fisher information, Optimal sampling times, Rate constant,
- MeSH
- Acrylates chemistry MeSH
- Time Factors MeSH
- Salicylic Acid chemistry MeSH
- Mannitol chemistry MeSH
- Solubility MeSH
- Models, Theoretical * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acrylates MeSH
- carbopol 71G MeSH Browser
- Salicylic Acid MeSH
- Mannitol MeSH
The aim is to determine how well the parameters of the Weibull model of dissolution can be estimated in dependency on the chosen times to measure the empirical data. The approach is based on the theory of Fisher information. We show that in order to obtain the best estimates the data should be collected at time instants when tablets actively dissolve or at their close proximity. This is in a sharp contrast with commonly used experimental protocols when sampling times are distributed rather uniformly.
References provided by Crossref.org
