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Efficacy of Bariatric Surgery in Type 2 Diabetes Mellitus Remission: the Role of Mini Gastric Bypass/One Anastomosis Gastric Bypass and Sleeve Gastrectomy at 1 Year of Follow-up. A European survey

Musella, Mario
Author Musella, Mario ORCID Department of Advanced Biomedical Sciences, "Federico II" University, Via S. Pansini 5, Building 12, 80131, Naples, Italy. mario.musella@unina.it
Apers, Jan
Author Apers, Jan Leeuwarden Medical Center, Leeuwarden, The Netherlands
Rheinwalt, Karl
Author Rheinwalt, Karl St. Franziskus Hospital, Cologne, Germany
Ribeiro, Rui
Author Ribeiro, Rui Centro Hospitalar de Lisboa Central, Lisbon, Portugal
Manno, Emilio
Author Manno, Emilio AORN "A. Cardarelli", Naples, Italy
Greco, Francesco
Author Greco, Francesco Clinica "Castelli", Bergamo, Italy
Čierny, Michal
Author Čierny, Michal Břeclav Hospital, Břeclav, Czech Republic
Milone, Marco
Author Milone, Marco Department of Advanced Biomedical Sciences, "Federico II" University, Via S. Pansini 5, Building 12, 80131, Naples, Italy
Di Stefano, Carla
Author Di Stefano, Carla AORN "G. Garibaldi", Catania, Italy
Guler, Sahin
Author Guler, Sahin Leeuwarden Medical Center, Leeuwarden, The Netherlands
Van Lessen, Isa Mareike
Author Van Lessen, Isa Mareike St. Franziskus Hospital, Cologne, Germany
Guerra, Anabela
Author Guerra, Anabela Centro Hospitalar de Lisboa Central, Lisbon, Portugal
Maglio, Mauro Natale
Author Maglio, Mauro Natale AORN "A. Cardarelli", Naples, Italy
Bonfanti, Riccardo
Author Bonfanti, Riccardo Clinica "Castelli", Bergamo, Italy
Novotna, Radoslava
Author Novotna, Radoslava Břeclav Hospital, Břeclav, Czech Republic
Coretti, Guido
Author Coretti, Guido Department of Advanced Biomedical Sciences, "Federico II" University, Via S. Pansini 5, Building 12, 80131, Naples, Italy
Piazza, Luigi
Author Piazza, Luigi AORN "G. Garibaldi", Catania, Italy

Obesity surgery. 2016 May ; 26 (5) : 933-40.

Obes Surg
ISSN 1708-0428 | 0960-8923
Source

Language English Country United States Media print

Document type Journal Article

Persistent link https://www.medvik.cz/link/pmid26341086

PubMed 26341086
DOI 10.1007/s11695-015-1865-6
PII: 10.1007/s11695-015-1865-6
Knihovny.cz E-resources

Keywords
Bariatric surgery, European multicenter survey, MGB/OAGB, Mini gastric bypass/one anastomosis gastric bypass, Remission, SG, Sleeve gastrectomy, T2DM, Type 2 diabetes mellitus,
MeSH
Diabetes Mellitus, Type 2 complications surgery MeSH
Adult MeSH
Gastrectomy methods MeSH
Weight Loss MeSH
Middle Aged MeSH
Humans MeSH
Obesity, Morbid complications surgery MeSH
Follow-Up Studies MeSH
Retrospective Studies MeSH
Treatment Outcome MeSH
Gastric Bypass methods MeSH
Health Surveys MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH

BACKGROUND: A retrospective study was undertaken to define the efficacy of both mini gastric bypass or one anastomosis gastric bypass (MGB/OAGB) and sleeve gastrectomy (SG) in type 2 diabetes mellitus (T2DM) remission in morbidly obese patients (pts). METHODS: Eight European centers were involved in this survey. T2DM was preoperatively diagnosed in 313/3252 pts (9.62%). In 175/313 patients, 55.9% underwent MGB/OAGB, while in 138/313 patients, 44.1% received SG between January 2006 and December 2014. RESULTS: Two hundred six out of 313 (63.7 %) pts reached 1 year of follow-up. The mean body mass index (BMI) for MGB/OAGB pts was 33.1 ± 6.6, and the mean BMI for SG pts was 35.9 ± 5.9 (p < 0.001). Eighty-two out of 96 (85.4%) MGB/OAGB pts vs. 67/110 (60.9%) SG pts are in remission (p < 0.001). No correlation was found in the % change vs. baseline values for hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) in relation to BMI reduction, for both MGB/OAGB or SG (ΔFPG 0.7 and ΔHbA1c 0.4 for MGB/OAGB; ΔFPG 0.7 and ΔHbA1c 0.1 for SG). At multivariate analysis, high baseline HbA1c [odds ratio (OR) = 0.623, 95% confidence interval (CI) 0.419-0.925, p = 0.01], preoperative consumption of insulin or oral antidiabetic agents (OR = 0.256, 95% CI 0.137-0.478, p = <0.001), and T2DM duration >10 years (OR = 0.752, 95% CI 0.512-0.976, p = 0.01) were negative predictors whereas MGB/OAGB resulted as a positive predictor (OR = 3.888, 95% CI 1.654-9.143, p = 0.002) of diabetes remission. CONCLUSIONS: A significant BMI decrease and T2DM remission unrelated from weight loss were recorded for both procedures if compared to baseline values. At univariate and multivariate analyses, MGB/OAGB seems to outperform significantly SG. Four independent variables able to influence T2DM remission at 12 months have been identified.

AORN A Cardarelli Naples Italy

AORN G Garibaldi Catania Italy

Břeclav Hospital Břeclav Czech Republic

Centro Hospitalar de Lisboa Central Lisbon Portugal

Clinica Castelli Bergamo Italy

Department of Advanced Biomedical Sciences Federico 2 University Via S Pansini 5 Building 12 80131 Naples Italy

Leeuwarden Medical Center Leeuwarden The Netherlands

St Franziskus Hospital Cologne Germany

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