The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin
Language English Country England, Great Britain Media print-electronic
Document type Journal Article
- Keywords
- Data visualization, disintegration time, dissolution profile, liquisolid systems, superdisintegrant,
- MeSH
- Anticholesteremic Agents administration & dosage chemistry MeSH
- Pharmaceutic Aids chemistry MeSH
- Povidone chemistry MeSH
- Drug Compounding MeSH
- Rosuvastatin Calcium administration & dosage chemistry MeSH
- Solubility MeSH
- Silicates chemistry MeSH
- Starch analogs & derivatives chemistry MeSH
- Aluminum Compounds chemistry MeSH
- Magnesium Compounds chemistry MeSH
- Tablets chemistry MeSH
- Drug Liberation MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- aluminum magnesium silicate MeSH Browser
- Anticholesteremic Agents MeSH
- Pharmaceutic Aids MeSH
- Povidone MeSH
- Rosuvastatin Calcium MeSH
- Silicates MeSH
- Starch MeSH
- Aluminum Compounds MeSH
- Magnesium Compounds MeSH
- sodium starch glycolate MeSH Browser
- Tablets MeSH
CONTEXT: The preparation of liquisolid systems (LSS) represents a promising method for enhancing a dissolution rate and bioavailability of poorly soluble drugs. The release of the drug from LSS tablets is affected by many factors, including the disintegration time. OBJECTIVE: The evaluation of differences among LSS containing varying amounts and types of commercially used superdisintegrants (Kollidon® CL-F, Vivasol® and Explotab®). MATERIALS AND METHODS: LSS were prepared by spraying rosuvastatin solution onto Neusilin® US2 and further processing into tablets. Varying amounts of superdisintegrants were used and the differences among LSS were evaluated. The multiple scatter plot method was used to visualize the relationships within the obtained data. RESULTS AND DISCUSSION: All disintegrants do not showed negative effect on the flow properties of powder blends. The type and concentration of superdisintegrant had an impact on the disintegration time and dissolution profiles of tablets. Tablets with Explotab® showed the longest disintegration time and the smallest amount of released drug. Fastest disintegration and dissolution rate were observed in tablets containing Kollidon® CL-F (≥2.5% w/w). Also tablets with Vivasol® (2.5-4.0% w/w) showed fast disintegration and complete drug release. CONCLUSION: Kollidon® CL-F and Vivasol® in concentration ≥2.5% are suitable superdisintegrants for LSS with enhanced release of drug.
References provided by Crossref.org