Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: a prospective multicentre study (WISS Study)
Status PubMed-not-MEDLINE Jazyk angličtina Země Anglie, Velká Británie Médium electronic-ecollection
Typ dokumentu časopisecké články
PubMed
26677396
PubMed Central
PMC4681030
DOI
10.1186/s13017-015-0055-0
PII: 55
Knihovny.cz E-zdroje
- Klíčová slova
- Infections, Intra-abdominal, Sepsis, Septic shock,
- Publikační typ
- časopisecké články MeSH
BACKGROUND: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. METHODS: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2 years (range 18-99) were enrolled in the WISS study. RESULTS: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2 %, a specificity of 83.5 % and a positive likelihood ratio of 5.4. CONCLUSIONS: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.
1st Department of Surgery Kavala General Hospital Kavala Greece
1st Department of Surgery Tzaneio Hospital Piraeus Greece
1st Surgical Clinic St Spiridon Hospital Iasi Romania
2nd Department of Surgery Aretaieio University Hospital Athens Greece
2nd Department of Surgery Jagiellonian University Medical College Krakow Poland
2nd Surgical Clinic Emergency Hospital of Craiova Craiova Romania
2nd Surgical Department General Hospital of Kavala Kavala Greece
3rd Department of General Surgery Jagiellonian Univeristy Collegium Medium Kraków Poland
3rd Department of Surgery Haepa University Hospital Thessaloniki Greece
3th Department of Surgery Iaso General Hospital Athens Greece
Abdominal and General Surgery Department General Hospital Jesenice Jesenice Slovenia
Abdominal Center University Hospital Meilahti Helsinki Finland
Chirurgia Generale Ospedale di Città di Castello Città di Castello Italy
Cirugía de Urgencias Hospital Universitario Donostia Donostia Spain
Cirugía General y Digestiva Hospital Universitario Miguel Servet Zaragoza Spain
Clinic for Emergency Surgery Medical Faculty University of Belgrade Belgrade Serbia
Clinical and Experimental Surgery Brescia Civil Hospital Brescia Italy
Departement of Surgery Fatabenefratelli Isola Tiberina Hspital Rome Italy
Department General Surgery Kipshidze Central University Hospital Tbilisi Georgia
Department of Emergency and Critical Care Medicine Jichi Medical University Shimotsuke Japan
Department of Emergency Surgery City Hospital Mozyr Belarus
Department of Emergency Surgery Maggiore Hospital Parma Italy
Department of Emergency Surgery Umberto 1 Hospital La Sapienza University Rome Italy
Department of General and Emergency Surgery SG Bosco Hospital Turin Italy
Department of General Surgery Al Ain Hospital Al Ain City United Arab Emirates
Department of General Surgery and Surgical Oncology Le Scotte Hospital Siena Italy
Department of General Surgery Emergency Municipal Hospital Pascani Pascani Iasi Romania
Department of General Surgery Hospital San Juan de Dios de La Serena La Serena Chile
Department of General Surgery Istanbul Training and Research Hospital Istanbul Turkey
Department of General Surgery Krishna Hospital Karad India
Department of General Surgery Lewisham and Greenwich NHS Trust London UK
Department of General Surgery Republican Vilnius University Hospital Vilnius Lithuania
Department of General Surgery Sakarya Teaching and Research Hospital Sakarya Turkey
Department of General Surgery Samsun Education and Research Hospital Samsun Turkey
Department of General Surgery Tan Tock Seng Hospital Novena Singapore
Department of General Surgery Trabzon Kanuni Training and Research Hospital Trabzon Turkey
Department of Laparoscopic and Metabolic Surgery Sunrise Hospital Kochi India
Department of Renal and Pancreas Transplantation Manchester Royal Infirmary Manchester UK
Department of Surgery Ahmadu Bello University Teaching Hospital Zaria Kaduna Nigeria
Department of Surgery Ascoli Piceno Hospital Ascoli Piceno Italy
Department of Surgery Bahrain Defence Force Hospital Manama Bahrain
Department of Surgery Baskent University Ankara Hospital Ankara Turkey
Department of Surgery Bharati Medical College and Hospital Sangli India
Department of Surgery Bizerte Hospital Bizerte Tunisia
Department of Surgery CH Armentieres Arras France
Department of Surgery CHVNG E EPE Vila Nova de Gaia Portugal
Department of Surgery Edendale Hospital Pietermaritzburg South Africa
Department of Surgery Elazig Training and Research Hospital Elazig Turkey
Department of Surgery Emergency Hospital of Bucharest Bucharest Romania
Department of Surgery Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand
Department of Surgery Fundación Jimenez Díaz Madrid Spain
Department of Surgery Good Hope Hospital Heart of England NHS Foundation Trust Birmingham UK
Department of Surgery Government Medical College and Hospital Chandigarh India
Department of Surgery Hamad General Hospital Doha Qatar
Department of Surgery Hospital and Comprehensive Cancer Centre Novy Jicin Novy Jicin Czech Republic
Department of Surgery Hospital de Alta Especialidad de Veracruz Veracruz Mexico
Department of Surgery Hospital Escola Padre Albino Catanduva Brazil
Department of Surgery Hospital La Paz Madrid Spain
Department of Surgery Hospital of Lithuanian University of Health Sciences Kaunas Lithuania
Department of Surgery Insubria University Hospital Varese Italy
Department of Surgery Insular University Hospital of Gran Canaria Las Palmas Spain
Department of Surgery King Abdalla University Hospital Irbid Jordan
Department of Surgery Kocaeli University Training and Research Hospital Kocaeli Turkey
Department of Surgery Kuala Krai Hospital Kelantan Malaysia
Department of Surgery Kwara State General Hospital Ilorin Nigeria
Department of Surgery LAUTECH Teaching Hospital Osogbo Nigeria
Department of Surgery Macerata Hospital Macerata Italy
Department of Surgery Maggiore Hospital Bologna Italy
Department of Surgery Mansoura University Hospital Mansoura Egypt
Department of Surgery Medical School University Pecs Pecs Hungary
Department of Surgery Mengucek Gazi Training Research Hospital Erzincan Turkey
Department of Surgery Montichiari Hospital Ospedali Civili Brescia Brescia Italy
Department of Surgery MOSC Medical College Kolenchery Cochin India
Department of Surgery North Estonia Medical Center Tallin Estonia
Department of Surgery Numune Training and Research Hospital Adana Turkey
Department of Surgery Onandjokwe Hospital Ondangwa Namibia
Department of Surgery Post Graduate Institute of Medical Sciences Rohtak India
Department of Surgery Radiology University Hospital of the West Indies Kingston Jamaica
Department of Surgery Rajendra Institute of Medical Sciences Ranchi India
Department of Surgery Red Cross Hospital Beverwijk Netherlands
Department of Surgery Regional Hospital Limbe Cameroon
Department of Surgery Riga East Clinical University Hospital Riga Latvia
Department of Surgery S M S Hospital Jaipur India
Department of Surgery Sant'Antonio Abate Hospital Gallarate Italy
Department of Surgery Tianjin Nankai Hospital Tianjin China
Department of Surgery UC San Diego Medical Center San Diego USA
Department of Surgery UMC Ljubljana Ljubljana Slovenia
Department of Surgery University Clinical Center of Kosovo Pristina Kosovo
Department of Surgery University Clinical Center Tuzla Bosnia and Herzegovina
Department of Surgery University Hospital Center Zagreb Croatia
Department of Surgery University Hospital of Larissa Larissa Greece
Department of Surgery University Hospital Valencia Spain
Department of Surgery University of Ilorin Teaching Hospital Ilorin Nigeria
Department of Surgery Yonsei University College of Medicine Seoul South Korea
Department of Surgery York Teaching Hospital NHS Foundation Trust York UK
Depatment of Surgery King Fahad Medical City Riyadh Saudi Arabia
Division Digestive Surgery and Urology Turku University Hospital Turku Finland
Division of Emergency and Trauma Surgery Ribeirão Preto Medical School Ribeirão Preto Brazil
Emergency Surgery Arcispedale S Anna Azienda Ospedaliero Universitaria di Ferrara Ferrara Italy
Fundación Valle del Lili Universidad del Valle Cali Colombia
General and Emergency Surgery Papa Giovanni XXIII Hospital Bergamo Italy
General and Emergency Surgery Policlinico Paolo Giaccone Palermo Italy
General and Upper GI Surgery Queen Elizabeth Hospital Birmingham UK
General Surgery Department Centro Hospitalar de São João Porto Portugal
General Surgery Department Medical University University Hospital St George Plovdiv Bulgaria
General Surgery Service Trauma University Hospital Tirana Albania
General Surgery ULSS19 del Veneto Adria RO Italy
Hospital Universitario del Valle Universidad del Valle Cali Colombia
King Fahad Medical City Riyadh Saudi Arabia
Primary Health Care Centre of Kissamos Chania Greece
Surgery 1 Unit Centro Hospitalar Tondela Viseu Viseu Portugal
Surgery Department University Hospital Hassan 2 Fez Morocco
Surgical 2 Division S Chiara Hospital Trento Italy
Trauma and Acute Care Surgery Unit Hadassah Hebrew University Medical Center Jerusalem Israel
Trauma and Emergency Surgery Department Chang Gung Memorial Hospital Taoyuan City Taiwan
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