Hepatoblastom, etiologie, kazuistiky
[Hepatoblastoma, Etiology, Case Reports]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
26691946
DOI
10.14735/amko2016s78
PII: 56906
- MeSH
- Beckwith-Wiedemann Syndrome complications MeSH
- Child MeSH
- Galactosemias complications MeSH
- Glycogen Storage Disease Type I complications MeSH
- Hepatitis B complications MeSH
- Hepatoblastoma etiology genetics MeSH
- Humans MeSH
- Liver Neoplasms etiology genetics MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Hepatoblastoma is an uncommon malignant neoplasm in general, yet, it is the most common liver malignancy in children with the incidence about one per milion children. This type of liver tumor usually occurs before the age of three years. The etiology of hepatoblastoma remains unknown. However, there are some genetic conditions known to be associated with an increased risk of developing hepatoblastoma such as Beckwith-Wiedemann syndrome, hemihypertrophy, APC-associated polyposis, α-1-antitrypsin defficiency and some metabolic disorders including tyrosinemia, galactosemia and glycogen storage disease type 1. There is a higher risk of hepatoblastoma in children with very low birthweight, children who acquire hepatitis B at an early age and children with congenital biliary atresia.
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