Influence of dermal exposure to ultraviolet radiation and coal tar (polycyclic aromatic hydrocarbons) on the skin aging process
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26748978
DOI
10.1016/j.jdermsci.2015.12.010
PII: S0923-1811(15)30095-5
Knihovny.cz E-resources
- Keywords
- 25-Hydroxy vitamin D, Chromosomal aberration, Oxidative stress, Polycyclic aromatic hydrocarbons, UV radiation,
- MeSH
- Administration, Cutaneous MeSH
- Biomarkers blood urine MeSH
- Time Factors MeSH
- Whole-Body Irradiation MeSH
- Chronic Disease MeSH
- Coal Tar administration & dosage adverse effects MeSH
- Adult MeSH
- Keratolytic Agents administration & dosage adverse effects MeSH
- Combined Modality Therapy MeSH
- Smoking adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Oxidative Stress drug effects radiation effects MeSH
- Polycyclic Aromatic Hydrocarbons administration & dosage adverse effects MeSH
- DNA Damage MeSH
- Psoriasis diagnosis metabolism therapy MeSH
- Pyrenes urine MeSH
- Aged MeSH
- RNA Stability drug effects radiation effects MeSH
- Skin Aging drug effects radiation effects MeSH
- Ultraviolet Therapy adverse effects methods MeSH
- Vitamin D analogs & derivatives blood MeSH
- Treatment Outcome MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1-hydroxypyrene MeSH Browser
- 25-hydroxyvitamin D MeSH Browser
- Biomarkers MeSH
- Coal Tar MeSH
- Keratolytic Agents MeSH
- Polycyclic Aromatic Hydrocarbons MeSH
- Pyrenes MeSH
- Vitamin D MeSH
BACKGROUND: Ultraviolet radiation (UVR) and crude coal tar (CCT) containing PAHs can accelerate the skin-aging process (SAP). However, UVR induces the formation of an important protective factor in SAP (vitamin D). OBJECTIVE: To determine the relation of SAP to selected risks and benefits of combined dermal exposure to UVR and coal tar (PAHs). METHODS: The study group consisted of patients with chronic stable plaque psoriasis and treated by Goeckerman therapy (GT; daily dermal application of UVR and 5% CCT ointment). The levels of urinary 1-hydroxypyrene (1-OHP), oxidative stress (DNA and RNA damage), genotoxic damage (chromosomal aberration in peripheral lymphocytes; ABC), 25-hydroxy-vitamin D [25(OH)D] and the PASI score were evaluated before and after GT. RESULTS: Intensive dermal absorption of PAHs was confirmed by increased levels of 1-OHP (p<0.01). After the therapy, we found an increased level of oxidative stress (p<0.05), an increased level of genotoxic damage (ABC; p<0.001), a high efficiency of the treatment (p<0.001) and an elevated production of 25(OH)D (p<0.01). We also found a relationship between the duration of UVR and the genotoxic damage (p<0.01), vitD (p<0.05) and the PASI score (p<0.05). Furthermore, we found a relationship between oxidative stress and 25(OH)D (p<0.05) and between genotoxic damage and the PASI score (p<0.05). CONCLUSION: Dermal exposure to UVR and coal tar (PAHs) enhances the level of oxidative stress and genotoxic damage and thus contributes to SAP. However, the exposure is very effective as a treatment and elevates the production of 25(OH)D, the protective factor in SAP. According to our results, UVR is probably a more hazardous factor in SAP.
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