The Steroidal Glycoalkaloids from Solanaceae: Toxic Effect, Antitumour Activity and Mechanism of Action
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26845708
DOI
10.1055/s-0042-100810
Knihovny.cz E-resources
- MeSH
- Solanaceous Alkaloids isolation & purification pharmacology toxicity MeSH
- Antineoplastic Agents, Phytogenic isolation & purification pharmacology toxicity MeSH
- Humans MeSH
- Plant Extracts isolation & purification pharmacology toxicity MeSH
- Solanaceae chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Solanaceous Alkaloids MeSH
- Antineoplastic Agents, Phytogenic MeSH
- Plant Extracts MeSH
Steroidal glycoalkaloids present in Solanaceae are toxic compounds biosynthesised for the protection of the plants. However, many health benefits of these compounds have been reported so far. One of their promising targets might be cancer, as demonstrated in a large number of studies. However, the main mechanism of action seems to be unclear. It could include the induction of apoptosis or trigger a necrosis with a subsequent inflammatory response. The relatively high systemic toxicity of steroidal compounds is another effect that must be taken into account in anticancer research. The main aim of this work was to summarise the recent progress in the investigation of the mechanisms of their antitumour action and to discuss their potential.
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