A chemoselective procedure for MCPBA oxidation of 26-thiodiosgenin to corresponding sulfoxides and sulfone was elaborated. An unusual equilibration of sulfoxides in solution was observed. Moreover, α-alkylation of sulfoxide and sulfone was investigated. Finally, the biological activity of obtained compounds was examined.

Department of Experimental Biology Faculty of Science Palacký University Šlechtitelů 27 CZ 78371 Olomouc Czech Republic

Laboratory of Molecular Biophysics Department of Microbiology and Biotechnology Faculty of Biology University of Bialystok K Ciołkowskiego 1 J 15 245 Białystok Poland

Laboratory of Natural Products Department of Organic Chemistry Faculty of Chemistry University of Bialystok K Ciołkowskiego 1K 15 245 Białystok Poland

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