Evaluation of muscle strength and manual dexterity in patients with Charcot-Marie-Tooth disease
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
26847322
DOI
10.1016/j.jht.2015.12.002
PII: S0894-1130(15)00184-2
Knihovny.cz E-resources
- Keywords
- Charcot-Marie-Tooth disease, Hand strength, Hereditary motor and sensory neuropathy, Manual dexterity, Sensory function,
- MeSH
- Charcot-Marie-Tooth Disease physiopathology MeSH
- Adult MeSH
- Functional Laterality physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Motor Skills physiology MeSH
- Neurologic Examination MeSH
- Aged MeSH
- Hand Strength physiology MeSH
- Muscle Strength Dynamometer MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
STUDY DESIGN: Matched pair study. INTRODUCTION: Differences in hand-muscle strength/dexterity between dominant (DH) and non-dominant (NDH) hand in Charcot-Marie-Tooth disease (CMT) are not well understood. PURPOSE OF THE STUDY: To compare muscle strength/dexterity between DH and NDH and to correlate manual dexterity, strength and sensory function. PATIENTS AND METHODS: Thirty CMT patients were studied using functional muscle testing (FMT) and strength (dynamometry), dexterity (the Nine Hole Peg Test [NHPT]), and Jebsen-Taylor Hand Function [JTT]), and sensory function (the Nottingham Sensory Assessment [NSA]). RESULTS: Scores were worse for DH than NDH on FMT (p = 0.043) and NHPT (p = 0.014) but not on JTT (p = 0.098), handgrip strength (p = 0.710) or tripod pinch (p = 0.645). NSA did not correlate significantly with any tests (p's0.05). CONCLUSIONS: In CMT disease, DH appears more impaired than NDH in terms of function and dexterity. Greater muscle weakness in DH may also emerge as CMT progresses. LEVEL OF EVIDENCE: 3b.
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