Recent reviews have highlighted conflicting findings regarding the validity of finger flexor strength and endurance tests in sport climbers, often due to small sample sizes and low ecological validity of the tests used. To address these gaps, 185 male and 122 female climbers underwent maximal finger flexor strength, intermittent and continuous finger flexor endurance, and the finger hang tests in a sport-specific setting to determine the predictive and concurrent validity of these tests. The finger hang test showed the strongest relationship to climbing ability for both sexes (R ≈ 0.75). However, despite its widespread use as an endurance test, the finger hang was found to be primarily determined by finger strength, explaining 65% and 80% of the variance in males and females, respectively. Finger strength emerged as the dominant factor, explaining the majority of variance in climbing ability (males 68%; females 64%), followed by intermittent endurance (males 28%; females 34%). These findings emphasize finger strength as the primary predictor of climbing ability and highlight the importance of intermittent endurance testing for assessing climbing-specific endurance of the finger flexors. No significant differences were found between male and female climbers in finger flexor strength and endurance when normalized to body mass.

• MeSH
• dospělí MeSH
• fyzická vytrvalost * fyziologie   MeSH
• horolezectví * fyziologie   MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• prsty ruky * fyziologie   MeSH
• reprodukovatelnost výsledků MeSH
• sexuální faktory MeSH
• síla ruky fyziologie   MeSH
• svalová síla fyziologie   MeSH
• zátěžový test metody   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• validační studie MeSH

BACKGROUND AND OBJECTIVES: Skeletal muscle is characterized by its mass, strength and performance. These normative values are pivotal in defining sarcopenia. Sarcopenia is associated with poor outcome of numerous medical and surgical conditions. This study aimed to establish normative benchmarks for skeletal muscle mass, strength and performance within the context of the Asian (Indian) population. METHODS: Our investigation utilized the computed tomography (CT) skeletal muscle index (SMI), handgrip strength (HGS), gait velocity and chair-stand test to construct reference values for muscle characteristics in the Indian population. RESULTS: The SMI analysis incorporated 1485 cases of acute abdomen (54.7%) males). The calculated SMI (kg/m2) was 38.50 (35.05-42.30) in males and 36.30 (32.20-41.20) in females (p = 0.510). The study also involved 3083 healthy individuals (67.6% males) evaluated for muscle strength and performance between August 2017 and August 2018. Notably, HGS (kg force) was recorded at 34.95 (26.50-43.30) in males and 25.50 (18.60-31.20) in females (p < 0.001). Gait velocity (metres/second) exhibited values of 1.25 (1.04-1.56) in males and 1.24 (1.03-1.56) in females (p = 0.851). Additionally, chair-stand test (seconds) results were 10.00 (9.00-13.00) in males and 12.00 (10.00-14.00) in females (p < 0.001). CONCLUSIONS: The investigation determined that males had greater muscle strength and performance than females. But gender wise, there was no significant difference in muscle mass. Interestingly, our population's muscle parameters were consistently lower compared to western literature benchmarks. These normative values will help to define sarcopenia parameters in our population, which have prognostic value in multiple ailments.

• MeSH
• dospělí MeSH
• kosterní svaly * diagnostické zobrazování   fyziologie   anatomie a histologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• počítačová rentgenová tomografie * MeSH
• referenční hodnoty MeSH
• rychlost chůze fyziologie   MeSH
• sarkopenie * diagnóza   patofyziologie   MeSH
• senioři MeSH
• síla ruky * fyziologie   MeSH
• svalová síla * fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Indie MeSH

PURPOSE OF THE STUDY: The aim of this study to evaluate the subjective and objective results of Extensor indicis proprius (EIP) to extensor pollicis longus (EPL) transfer with an emphasis on donor site morbidity. MATERIAL AND METHODS: 17 patients (59% men, 41% women) who underwent EIP-EPL transfer were retrospectively analyzed. The mean age was 43 (9-64) years, and the mean follow-up was 72 (19-124) months. The extensor strengths were measured according to the Medical Research Council (MRC) scoring system. Nail tip-table surface distance (NTD) was measured to evaluate extension loss, and pulp-palm distance (PPD) to evaluate thumb flexion-adduction limitation. Grip and key pinch strengths were measured and corrected regarding the dominance and compared with those of the non-operated side. Quick Disability of Arm, Shoulder, and Hand (QDASH) and satisfaction scores of the patients were evaluated. RESULTS: Donor site morbidity was detected in 6 patients (35%). The extension strength of the index finger was found to be significantly lower than the non-operative side (p<0.05). Thumb mean NTD and PPD values were 6.8 (0-50) and 2.9 (0-20) mm, respectively. The index finger mean NTD was 0.6 (0-10) mm. The grip strength was 86% (43%-100%) and the pinch strength was 82% (31-100%) of the expected strengths. Compared to the preoperative period, there was a significant decrease in the QDASH score (p <0.05). Postoperative QDASH scores of patients with donor site morbidity were significantly higher than those without (p <0.05). CONCLUSIONS: Although patients are generally satisfied with the EIP-EPL transfer results, the permanent morbidity rate in the index finger is high. Therefore, alternatives other than EIP should be considered for transfer to EPL in individuals whose occupation requires complete and strong index finger extension. KEY WORDS: extensor pollicis longus, neglected tendon laceration, extensor indicis proprius, tendon transfer, donor site morbidity.

• MeSH
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• palec ruky chirurgie   fyziologie   MeSH
• přenos šlachy * metody   MeSH
• retrospektivní studie MeSH
• rozsah kloubních pohybů MeSH
• síla ruky fyziologie   MeSH
• výsledek terapie MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

OBJECTIVES: The aims of the study were to investigate the relationship between sarcopenia and renin-angiotensin system-related disorders and to explore the effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on muscle mass/function and physical performance. DESIGN: This multicenter, cross-sectional study was performed using ISarcoPRM algorithm for the diagnosis of sarcopenia. RESULTS: Of the 2613 participants (mean age = 61.0 ± 9.5 yrs), 1775 (67.9%) were hypertensive. All sarcopenia-related parameters (except chair stand test in males) were worse in hypertensive group than in normotensive group (all P < 0.05). When clinical/potential confounders were adjusted, hypertension was found to be an independent predictor of sarcopenia in males (odds ratio = 2.403 [95% confidence interval = 1.514-3.813]) and females (odds ratio = 1.906 [95% confidence interval = 1.328-2.734], both P < 0.001). After adjusting for confounding factors, we found that all sarcopenia-related parameters (except grip strength and chair stand test in males) were independently/negatively related to hypertension (all P < 0.05). In females, angiotensin-converting enzyme inhibitors users had higher grip strength and chair stand test performance values but had lower anterior thigh muscle thickness and gait speed values, as compared with those using angiotensin II receptor blockers (all P < 0.05). CONCLUSIONS: Hypertension was associated with increased risk of sarcopenia at least 2 times. Among antihypertensives, while angiotensin-converting enzyme inhibitors had higher muscle function values, angiotensin II receptor blockers had higher muscle mass and physical performance values only in females.

• MeSH
• antagonisté receptorů pro angiotenzin farmakologie   MeSH
• hypertenze * MeSH
• inhibitory ACE škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• průřezové studie MeSH
• sarkopenie * diagnóza   MeSH
• senioři MeSH
• síla ruky fyziologie   MeSH
• svalová síla fyziologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH

V rámci epidemiologické studie byla v období 2020–2021 monitorována maximální svalová síla stisku ruky dospělé populace České republiky. V souvislosti s měřením lokální svalové zátěže horních končetin metodou integrované elektromyografie, která je od 90. let 20. století nedílnou součástí při hodnocení poškození zdraví z práce, se jedná o nejdůležitější údaj z hlediska interpretace výsledků měření. Autoři předkládají statistickou analýzu rozsáhlé studie, jež byla zpracována z důvodu nezbytné standardizace metodických postupů autorizovaných laboratoří.

As part of an epidemiological study, the maximum handshake muscle strength of the adult population of the Czech Republic was monitored in the period 2020–2021. In connection with the measurement of the local muscle load of the upper limbs by the method of integrated electromyography, which has been an integral part of the assessment of work-related health damage since the 1990s, this is the most important data from the point of view of the interpretation of the measurement results. The authors present a statistical analysis of an extensive study, which was prepared due to the necessary standardization of methodological procedures of authorized laboratories.

• MeSH
• dospělí MeSH
• elektromyografie MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• pracovní zátěž MeSH
• senioři MeSH
• síla ruky * fyziologie   MeSH
• tělesná námaha MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Česká republika MeSH

Myasthenia gravis (MG) is an autoimmune disease characterized by fatigable muscle weakness. Despite full spontaneous or pharmacological remission some MG patients still complain of physical and mental fatigue. Fatigue has been related to autonomic dysregulation. The aim of this study was to assess autonomic responses in a group of MG patients in complete remission but complaining of persistent fatigue. Seventeen well-regulated but persistently fatigued MG patients and 17 individually matched controls underwent echocardiography assessing systolic and diastolic heart function. Beat to beat cardiovascular responses at rest and to 30o head-up tilt, tilt-back, and 2-min static handgrip contraction were recorded. Fatigued MG patients had a statistically significant higher resting HR than their matched controls (p=0.03). The difference in resting heart rate between MG patients not using acetylcholine esterase inhibitors (AChEi) and their matched controls was even more pronounced (p=0.007). The autonomic cardiovascular adjustments to head-up tilt, tilt-back and handgrip contraction were not statistically significant different between patients and controls. We found a higher resting heart rate in all well-regulated but fatigued MG patients compared with controls. The difference was more pronounced between patients not taking AChEi compared to their matched controls. This finding may reflect a disturbed resting sympathovagal balance and this might be a contributing factor to the fatigue symptoms.

• MeSH
• autonomní nervový systém MeSH
• krevní tlak fyziologie   MeSH
• lidé MeSH
• myasthenia gravis * komplikace   diagnóza   MeSH
• nemoci autonomního nervového systému * MeSH
• síla ruky fyziologie   MeSH
• srdeční frekvence fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

PURPOSE: Sarcopenic obesity (SO) as a new diagnostic entity defined by presence of obesity in combination with sarcopenia represents serious health condition negatively affecting quality of life in old age. Despite the rapidly increasing incidence of SO associated with demographic aging, clear diagnostic criteria for SO have not yet been established. We describe here the applicability of the EWGSOP2 and EWGSOP1 diagnostic criteria in identifying sarcopenia and SO and the development of a refinement algorithm for SO detection. METHODS: In total 156 subjects were pre-screened, 126 had a complete dataset and were included, 20.6% (n = 26) were men and 79.4% (n = 100) women, mean age 81 ± 6.3 years in tertiary hospital, Prague, Czech Republic. Testing of physical performance (hand-grip test, 400 m walk test, chair stand test, gait speed), anthropometric measures and SARC-F, SPPB and MNA-SF were used to determine physical, functional, and nutritional status, while muscle mass and fat mass were measured by DXA scans to confirm sarcopenia and SO diagnosis. RESULTS: The prevalence of sarcopenia (BMI adjusted ALM < 0.789 for men, < 0.512 for women) was 26.2% (n = 33), SO in 20.6% (n = 26). 78.8% of all sarcopenic subjects fulfilled the criteria of SO (FM > 27% for men and > 38% for women; waist circumference > 90 cm for men and > 85 cm for women). EWGSOP1 criteria for diagnosing sarcopenia showed better sensitivity of 97.0% than the EWGSOP2 66.7%, while specificity reached 100% for both criteria. According to DXA measurement, EWGSOP1 identified 3.0% cases (1 out of 33) as false negative meanwhile EWGSOP2 identified 33.3% cases as false negative and this difference was statistically significant (McNemar's test, p < 0.001). An algorithm for SO was developed (which uses sex, BMI, height, waist circumference and SPPB) with sensitivity and specificity of 88.5 and 91.0%, respectively. CONCLUSION: High prevalence of obesity among elderly people and rather low sensitivity of current diagnostic criteria for SO call for ongoing research. Broader international consensus for SO diagnostic criteria, screening and diagnosis algorithm are crucial for early detection of SO in older people in clinical practice so that optimal multi-component therapy can be initiated.

• MeSH
• algoritmy MeSH
• kvalita života MeSH
• lidé MeSH
• obezita komplikace   diagnóza   epidemiologie   MeSH
• sarkopenie * diagnóza   epidemiologie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• síla ruky fyziologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

PURPOSE: Sport climbing requires high-intensity finger flexor contractions, along with a substantial whole-body systemic oxygen uptake ([Formula: see text]O2) contribution. Although fatigue is often localised to the finger flexors, the role of systemic ̇[Formula: see text]O2 and local aerobic mechanisms in climbing performance remains unclear. As such, the primary purpose of this study was to determine systemic and local muscle oxygen responses during both isolated finger flexion and incremental exhaustive whole-body climbing tests. The secondary aim was to determine the relationship of isolated and whole-body climbing endurance tests to climbing ability. METHODS: Twenty-two male sport climbers completed a series of isometric sustained and intermittent forearm flexor contractions, and an exhaustive climbing test with progressive steepening of the wall angle on a motorised climbing ergometer. Systemic [Formula: see text]O2 and flexor digitorum profundus oxygen saturation (StO2) were recorded using portable metabolic analyser and near-infra red spectroscopy, respectively. RESULTS: Muscle oxygenation breakpoint (MOB) was identifiable during an incremental exhaustive climbing test with progressive increases in angle (82 ± 8% and 88 ± 8% [Formula: see text]O2 and heart rate climbing peak). The peak angle from whole-body treadwall test and impulse from isolated hangboard endurance tests were interrelated (R2 = 0.58-0.64). Peak climbing angle together with mean [Formula: see text]O2 and StO2 from submaximal climbing explained 83% of variance in self-reported climbing ability. CONCLUSIONS: Both systemic and muscle oxygen kinetics determine climbing-specific endurance. Exhaustive climbing and isolated finger flexion endurance tests are interrelated and suitable to assess climbing-specific endurance. An exhaustive climbing test with progressive wall angle allows determination of the MOB.

• MeSH
• blízká infračervená spektroskopie MeSH
• dospělí MeSH
• fyzická vytrvalost fyziologie   MeSH
• horolezectví fyziologie   MeSH
• kosterní svaly fyziologie   MeSH
• lidé MeSH
• prsty ruky fyziologie   MeSH
• síla ruky fyziologie   MeSH
• spotřeba kyslíku fyziologie   MeSH
• svalová kontrakce fyziologie   MeSH
• svalová únava fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

The purpose of the study was to compare the psychophysiological response of climbers of a range of abilities (lower grade to advanced) when ascending identical climbing routes on a climbing wall and a rotating treadwall. Twenty-two female climbers (31.2 ± 9.4 years; 60.5 ± 6.5 kg; 168.6 ± 5.7 cm) completed two identical 18 m climbing trials (graded 4 on the French Sport scale) separated by 1 week, one on the treadwall (climbing low to the ground) and the other on the indoor wall (climbing in height). Indirect calorimetry, venous blood samples and video-analysis were used to assess energy cost, hormonal response and time-load characteristics. Energy costs were higher during indoor wall climbing comparing to those on the treadwall by 16% (P < 0.001, [Formula: see text] = 0.48). No interaction of climbing ability and climbing condition were found. However, there was an interaction for climbing ability and post-climbing catecholamine concentration (P < 0.01, [Formula: see text] = 0.28). Advanced climbers' catecholamine response increased by 238% and 166% with respect to pre-climb values on the treadwall and indoor wall, respectively; while lower grade climbers pre-climb concentrations were elevated by 281% and 376% on the treadwall and indoor wall, respectively. The video analysis showed no differences in any time-motion variables between treadwall and indoor wall climbing. The study demonstrated a greater metabolic response for indoor wall climbing, however, the exact mechanisms are not yet fully understood.

• MeSH
• dospělí MeSH
• horolezectví fyziologie   MeSH
• lidé MeSH
• psychofyziologie normy   statistika a číselné údaje   MeSH
• síla ruky fyziologie   MeSH
• sportovní výkon fyziologie   MeSH
• spotřeba kyslíku fyziologie   MeSH
• srdeční frekvence fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance, and altered mitochondrial function. We used a cross-sectional study design with well-matched fit and (pre-)frail old males and females, using young males and females as healthy controls. Frailty was assessed according to the Fried criteria and physical performance was determined by 400 m walk test, short physical performance battery and handgrip strength. Muscle and plasma acylcarnitine status, and muscle mitochondrial gene expression was analyzed. Results showed that intramuscular total carnitine levels and short-chain acylcarnitine levels were lower in (pre-)frail old females compared to fit old females and young females, whereas no differences were observed in males. The low intramuscular short-chain acylcarnitine levels in females correlated with low physical performance, even after correction for muscle mass (%), and were accompanied with lowered expression of genes involved in mitochondrial energy production and functionality. It is, therefore, concluded that in (pre-)frail old females, intramuscular total carnitine levels and short-chain acylcarnitine levels are decreased, and this decrease is associated with reduced physical performance and low expression of a wide range of genes critical for mitochondrial function. The results stress the importance of taking sex differences into account in aging research.

• MeSH
• chůze fyziologie   MeSH
• karnitin analogy a deriváty   krev   chemie   metabolismus   MeSH
• křehkost metabolismus   patofyziologie   MeSH
• křehký senior MeSH
• lidé MeSH
• průřezové studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• sexuální faktory MeSH
• síla ruky fyziologie   MeSH
• stárnutí metabolismus   fyziologie   MeSH
• svaly metabolismus   MeSH
• tělesná výkonnost fyziologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH