Dual-modality self-heating and antibacterial polymer-coated nanoparticles for magnetic hyperthermia
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27040199
DOI
10.1016/j.msec.2016.02.052
PII: S0928-4931(16)30142-4
Knihovny.cz E-zdroje
- Klíčová slova
- Antibacterial properties, Hyperthermia, Magnetic, Self-heating,
- MeSH
- antibakteriální látky chemie farmakologie MeSH
- biofilmy účinky léků MeSH
- Escherichia coli účinky léků fyziologie MeSH
- indukovaná hypertermie MeSH
- magnetické nanočástice chemie MeSH
- methylcelulosa chemie MeSH
- polyethylenimin chemie MeSH
- spektroskopie infračervená s Fourierovou transformací MeSH
- Staphylococcus aureus účinky léků fyziologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- magnetické nanočástice MeSH
- methylcelulosa MeSH
- polyethylenimin MeSH
Multifunctional nanoparticles for magnetic hyperthermia which simultaneously display antibacterial properties promise to decrease bacterial infections co-localized with cancers. Current methods synthesize such particles by multi-step procedures, and systematic comparisons of antibacterial properties between coatings, as well as measurements of specific absorption rate (SAR) during magnetic hyperthermia are lacking. Here we report the novel simple method for synthesis of magnetic nanoparticles with shells of oleic acid (OA), polyethyleneimine (PEI) and polyethyleneimine-methyl cellulose (PEI-mC). We compare their antibacterial properties against single gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria as well as biofilms. Magnetite nanoparticles (MNPs) with PEI-methyl cellulose were found to be most effective against both S. aureus and E. coli with concentration for 10% growth inhibition (EC10) of <150 mg/l. All the particles have high SAR and are effective for heat-generation in alternating magnetic fields.
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