Dual-modality self-heating and antibacterial polymer-coated nanoparticles for magnetic hyperthermia
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
27040199
DOI
10.1016/j.msec.2016.02.052
PII: S0928-4931(16)30142-4
Knihovny.cz E-resources
- Keywords
- Antibacterial properties, Hyperthermia, Magnetic, Self-heating,
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Biofilms drug effects MeSH
- Escherichia coli drug effects physiology MeSH
- Hyperthermia, Induced MeSH
- Magnetite Nanoparticles chemistry MeSH
- Methylcellulose chemistry MeSH
- Polyethyleneimine chemistry MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Staphylococcus aureus drug effects physiology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Magnetite Nanoparticles MeSH
- Methylcellulose MeSH
- Polyethyleneimine MeSH
Multifunctional nanoparticles for magnetic hyperthermia which simultaneously display antibacterial properties promise to decrease bacterial infections co-localized with cancers. Current methods synthesize such particles by multi-step procedures, and systematic comparisons of antibacterial properties between coatings, as well as measurements of specific absorption rate (SAR) during magnetic hyperthermia are lacking. Here we report the novel simple method for synthesis of magnetic nanoparticles with shells of oleic acid (OA), polyethyleneimine (PEI) and polyethyleneimine-methyl cellulose (PEI-mC). We compare their antibacterial properties against single gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria as well as biofilms. Magnetite nanoparticles (MNPs) with PEI-methyl cellulose were found to be most effective against both S. aureus and E. coli with concentration for 10% growth inhibition (EC10) of <150 mg/l. All the particles have high SAR and are effective for heat-generation in alternating magnetic fields.
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