As a part of cellular pathogen defense, IFNγ triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Recent data show that a similar mechanism can also operate in IFNγ-mediated anticancer control. IFNγ is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumor cells leading to generation of reactive oxygen species (ROS) damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence.

Department of Genome Integrity of Institute of Molecular Genetics of the ASCR v v i Prague Czech Republic

Department of Genome Integrity of Institute of Molecular Genetics of the ASCR v v i Prague Czech Republic; Danish Cancer Society Research Center Copenhagen Denmark

Immunology Unit CCP Institute of Molecular Genetics of the ASCR v v i Prague Czech Republic

Laboratory of Cell Reproduction Institute of Microbiology of the ASCR v v i Prague Czech Republic

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