Construction of antibacterial poly(ethylene terephthalate) films via layer by layer assembly of chitosan and hyaluronic acid
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27083341
DOI
10.1016/j.carbpol.2016.02.008
PII: S0144-8617(16)30048-0
Knihovny.cz E-zdroje
- Klíčová slova
- Chitosan, Hyaluronic acid, Poly(ethylene terephthalate) aminolysis, Polyelectrolyte multilayers,
- MeSH
- antibakteriální látky chemie farmakologie MeSH
- biokompatibilní potahované materiály chemie farmakologie MeSH
- chitosan analogy a deriváty chemie farmakologie MeSH
- Escherichia coli účinky léků MeSH
- fluorescein-5-isothiokyanát chemie MeSH
- hyaluronoglukosaminidasa chemie MeSH
- kyselina hyaluronová analogy a deriváty chemie farmakologie MeSH
- muramidasa chemie MeSH
- polyethylentereftaláty chemie farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- biokompatibilní potahované materiály MeSH
- chitosan MeSH
- fluorescein-5-isothiokyanát MeSH
- hyaluronoglukosaminidasa MeSH
- kyselina hyaluronová MeSH
- muramidasa MeSH
- polyethylentereftaláty MeSH
Polyelectrolytic multilayers (PEMs) with enhanced antibacterial properties were built up onto commercial poly(ethylene terephthalate) (PET) films based on the layer by layer assembling of bacterial contact killing chitosan and bacterial repelling highly hydrated hyaluronic acid. The optimization of the aminolysis modification reaction of PET was carried out by the study of the mechanical properties and the surface characterization of the modified polymers. The layer by layer assembly was successfully monitored by TEM microscopy, surface zeta-potential, contact angle measurements and, after labeling with fluorescein isothiocyanate (FTIC) by absorption spectroscopy and confocal fluorescent microscopy. Beside, the stability of the PEMs was studied at physiological conditions in absence and in the presence of lysozyme and hyaluronidase enzymes. Antibacterial properties of the obtained PEMs against Escherichia coli were compared with original commercial PET.
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