Chronic pancreatitis and the composition of plasma phosphatidylcholine fatty acids
Language English Country Scotland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
27154363
DOI
10.1016/j.plefa.2016.03.012
PII: S0952-3278(16)30013-8
Knihovny.cz E-resources
- Keywords
- Chronic pancreatitis, Diabetes mellitus, Discriminant analysis, Fatty acid profile, Malnutrition,
- MeSH
- Pancreatitis, Chronic metabolism MeSH
- Adult MeSH
- Phosphatidylcholines analysis blood MeSH
- Fatty Acids, Monounsaturated blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipid Metabolism MeSH
- Fatty Acids, Unsaturated blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Phosphatidylcholines MeSH
- Fatty Acids, Monounsaturated MeSH
- Fatty Acids, Unsaturated MeSH
Chronic pancreatitis (CP) is an irreversible inflammatory disorder characterized by the destruction of both exocrine and endocrine tissue. There is growing evidence that dysregulation of fatty acid (FA) metabolism is connected with many diseases; however, there are few data concerning FA composition in CP. Therefore, we analyzed FA profiles in plasma phosphatidylcholines in 96 patients with CP and in 108 control subjects (CON). The patients with CP had, in comparison with CON, increased sum of monounsaturated FA (ΣMUFA) and decreased content of polyunsaturated FA (PUFA) in both n-6 and n-3 families. Moreover, CP patients had increased indexes for delta-9, delta-6 desaturases, and fall in activity of delta-5 desaturase. Increased ratio of 16:1n-7/18:2n-6 (marker of essential n-6 FA deficiency), was more prevalent among CP patients. These changes implicated decreased fat intake, including n-3 as well as n-6 PUFA, and intrinsic changes in FA metabolism due to the alteration of delta desaturase activities.
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