Chronic pancreatitis and the composition of plasma phosphatidylcholine fatty acids
Jazyk angličtina Země Scotland Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27154363
DOI
10.1016/j.plefa.2016.03.012
PII: S0952-3278(16)30013-8
Knihovny.cz E-zdroje
- Klíčová slova
- Chronic pancreatitis, Diabetes mellitus, Discriminant analysis, Fatty acid profile, Malnutrition,
- MeSH
- chronická pankreatitida metabolismus MeSH
- dospělí MeSH
- fosfatidylcholiny analýza krev MeSH
- kyseliny mastné mononenasycené krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- metabolismus lipidů MeSH
- nenasycené mastné kyseliny krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- fosfatidylcholiny MeSH
- kyseliny mastné mononenasycené MeSH
- nenasycené mastné kyseliny MeSH
Chronic pancreatitis (CP) is an irreversible inflammatory disorder characterized by the destruction of both exocrine and endocrine tissue. There is growing evidence that dysregulation of fatty acid (FA) metabolism is connected with many diseases; however, there are few data concerning FA composition in CP. Therefore, we analyzed FA profiles in plasma phosphatidylcholines in 96 patients with CP and in 108 control subjects (CON). The patients with CP had, in comparison with CON, increased sum of monounsaturated FA (ΣMUFA) and decreased content of polyunsaturated FA (PUFA) in both n-6 and n-3 families. Moreover, CP patients had increased indexes for delta-9, delta-6 desaturases, and fall in activity of delta-5 desaturase. Increased ratio of 16:1n-7/18:2n-6 (marker of essential n-6 FA deficiency), was more prevalent among CP patients. These changes implicated decreased fat intake, including n-3 as well as n-6 PUFA, and intrinsic changes in FA metabolism due to the alteration of delta desaturase activities.
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