The effect of tramadol hydrochloride on early life stages of fish
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
27208654
DOI
10.1016/j.etap.2016.05.006
PII: S1382-6689(16)30099-0
Knihovny.cz E-resources
- Keywords
- Aquatic contamination, Cyprinus carpio, Danio rerio, Oxidative stress, Toxicity test,
- MeSH
- Water Pollutants, Chemical toxicity MeSH
- Zebrafish embryology growth & development MeSH
- Embryo, Nonmammalian drug effects MeSH
- Embryonic Development drug effects MeSH
- Carps growth & development MeSH
- Toxicity Tests, Acute MeSH
- Tramadol toxicity MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Water Pollutants, Chemical MeSH
- Tramadol MeSH
The aim of this study was to perform the fish embryo acute toxicity test (FET) on zebrafish (Danio rerio) and the early-life stage toxicity test on common carp (Cyprinus carpio) with tramadol hydrochloride. The FET was performed using the method inspired by the OECD guideline 236. Newly fertilized zebrafish eggs were exposed to tramadol hydrochloride at concentrations of 10; 50; 100 and 200μg/l for a period of 144h. An embryo-larval toxicity test on C. carpio was performed according to OECD guideline 210 also with tramadol hydrochloride at concentrations 10; 50; 100 and 200μg/l for a period of 32 days. Hatching was significantly influenced in both acute and subchronic toxicity assays. Subchronic exposure also influenced early ontogeny, both morphometric and condition characteristics and caused changes in antioxidant enzyme activity. The LOEC value was found to be 10μg/l tramadol hydrochloride.
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