Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
27468921
DOI
10.1007/s00280-016-3114-7
PII: 10.1007/s00280-016-3114-7
Knihovny.cz E-resources
- Keywords
- Colorectal cancer, Immunohistochemistry, Prognosis, Protein,
- MeSH
- ATP-Binding Cassette Transporters metabolism MeSH
- Fluorouracil therapeutic use MeSH
- Colorectal Neoplasms drug therapy pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Recurrence, Local MeSH
- Survival Rate MeSH
- Follow-Up Studies MeSH
- Disease-Free Survival MeSH
- Prognosis MeSH
- Multidrug Resistance-Associated Proteins metabolism MeSH
- Antimetabolites, Antineoplastic therapeutic use MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- ABCC10 protein, human MeSH Browser
- ABCC11 protein, human MeSH Browser
- Fluorouracil MeSH
- Multidrug Resistance-Associated Proteins MeSH
- Antimetabolites, Antineoplastic MeSH
PURPOSE: This study investigated the prognostic importance of protein expression of ATP-binding cassette (ABC) transporters ABCC10 and ABCC11 in colorectal cancer. METHODS: Protein content of ABCC10 and ABCC11 was assessed in tumor tissue blocks of 140 colorectal cancer patients and associated with survival of patients with regard to 5-fluorouracil-based therapy. RESULTS: Low ABCC10 protein content in tumors increased hazard ratio of patient's death more than three times in comparison with high ABCC10-expressing tumors (P = 0.004). In contrast, the low ABCC11 content increased the hazard ratio of cancer recurrence in patients almost four times (P = 0.016). Analysis of patients treated with regimens based on 5-fluorouracil revealed that patients with low ABCC11 content in their tumors had shorter disease-free interval than those with higher content (P = 0.024). CONCLUSIONS: The present study shows for the first time that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients and provides strong impulse for further validation of their prognostic value in colorectal cancer.
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