Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27496049
DOI
10.1016/j.ejps.2016.08.002
PII: S0928-0987(16)30291-3
Knihovny.cz E-zdroje
- Klíčová slova
- Co-processed dry binders, Dissolution kinetics, Hypromellose, Matrix tablets, Tramadol hydrochloride,
- MeSH
- deriváty hypromelózy chemie farmakokinetika MeSH
- farmaceutická chemie metody MeSH
- hydrofobní a hydrofilní interakce * MeSH
- rozpustnost MeSH
- tablety MeSH
- tramadol chemie farmakokinetika MeSH
- uvolňování léčiv MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- deriváty hypromelózy MeSH
- tablety MeSH
- tramadol MeSH
The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel™ Premium CR cannot control the tramadol release effectively for >12h and tablets containing Disintequik™ MCC 25 and Methocel™ Premium CR >8h.
Citace poskytuje Crossref.org
