Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
27496049
DOI
10.1016/j.ejps.2016.08.002
PII: S0928-0987(16)30291-3
Knihovny.cz E-resources
- Keywords
- Co-processed dry binders, Dissolution kinetics, Hypromellose, Matrix tablets, Tramadol hydrochloride,
- MeSH
- Hypromellose Derivatives chemistry pharmacokinetics MeSH
- Chemistry, Pharmaceutical methods MeSH
- Hydrophobic and Hydrophilic Interactions * MeSH
- Solubility MeSH
- Tablets MeSH
- Tramadol chemistry pharmacokinetics MeSH
- Drug Liberation MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hypromellose Derivatives MeSH
- Tablets MeSH
- Tramadol MeSH
The aim of this study is to present the possibility of using of co-processed dry binders for formulation of matrix tablets with drug controlled release. Hydrophilic matrix tablets with tramadol hydrochloride, hypromellose and different co-processed dry binders were prepared by direct compression method. Hypromelloses Methocel™ K4M Premium CR or Methocel™ K100M Premium CR were used as controlled release agents and Prosolv® SMCC 90 or Disintequik™ MCC 25 were used as co-processed dry binders. Homogeneity of the tablets was evaluated using scanning electron microscopy and energy dispersive X-ray microanalysis. The release of tramadol hydrochloride from prepared formulations was studied by dissolution test method. The dissolution profiles obtained were evaluated by non-linear regression analysis, release rate constants and other kinetic parameters were determined. It was found that matrix tablets based on Prosolv® SMCC 90 and Methocel™ Premium CR cannot control the tramadol release effectively for >12h and tablets containing Disintequik™ MCC 25 and Methocel™ Premium CR >8h.
References provided by Crossref.org
