Candidal intertrigo is an infection of the skin caused by Candida albicans that typically occurs in opposing cutaneous or muco-cutaneous surfaces. Because Candidiasis requires a damaged and moist environment for infection, it typically occurs in areas of friction such as the skin folds of the body. Candidal intertrigo is often difficult to treat and results are often unsatisfactory. In addition, there is a lack of evidence-based literature supporting prevention and treatments for candidal intertrigo. The aim of the study was to evaluate the efficacy of Dr Michaels® (also branded as Fungatinex®) products in the treatment of fungal intertrigo, in 20 women and 2 men with a mean age of 72. Five patients (3 female and 2 male) had type 2 diabetes and 16 (14 female and 2 male) were obese. The patients were treated with Dr Michaels® (Fungatinex®) moisturising bar, topical ointment (twice daily application) and oral herbal formulation, PSC 200 two tablets twice daily with food. After 2 weeks of treatment, the lesions had mostly resolved in all patients with only slight erythema evident. After six weeks of treatment using the moisturising bar, topical ointment and oral herbal formulations from the Dr Michaels® (Fungatinex®) product family, the lesions had totally resolved in 18 patients, while 4 patients had to continue the therapeutic protocol for another 2 weeks. Our results demonstrate that the Dr Michaels® (Fungatinex®) complementary product family is efficacious in the treatment of recalcitrant candidal intertrigo. Furthermore, this study highlights that the Dr Michaels® (Fungatinex®) product family is fast-acting and well tolerated with no serious adverse events reported. These data have important implications for resistant cases of candidal intertrigo where traditional therapies have failed.

2nd Medical Faculty Charles University Bulovka Hospital Institute of Clinical and Experimental Medicine Prague Czech Republic

Chair of Dermatology University of Rome “G Marconi” Rome Italy

Department “Medicinal Information and Non interventional studies” Bulgarian Drug Agency Sofia Bulgaria

Department of Dermatology and Allergology Academic Teaching Hospital Dresden Friedrichstadt Dresden Germany

Department of Dermatology and Cutaneous Surgery Department of Psychiatry and Behavioral Sciences Institute for Bioethics and Health Policy University of Miami Miller School of Medicine Miami FL USA; Centro Studi per la Ricerca Multidisciplinare e Rigenerativa Università Degli Studi G Marconi Rome Italy

Department of Nuclear Physics Sub nuclear and Radiation Guglielmo Marconi University Rome Italy

Dermatological Department University of Pisa Pisa Italy

Medical Institute of Ministry of Interior Department of Dermatology Venereology and Dermatologic Surgery Sofia Bulgaria

”Onkoderma” Policlinic for dermatology and dermatologic surgery Sofia Bulgaria; Department of Dermatology and Venereology Medical University of Plovdiv Medical faculty Plovdiv Bulgaria

PRO SANUM Ltd Sanatorium of Prof Novotný Štěpánská Prague 1 Czech Republic

Psoriasis and Skin Clinic Melbourne Australia

University B 1 S Group of Institutions Punjab Technical University Punjab India