Quambalarine B, a Secondary Metabolite from Quambalaria cyanescens with Potential Anticancer Properties
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
- MeSH
- antitumorózní látky krev chemie izolace a purifikace farmakologie MeSH
- Basidiomycota chemie MeSH
- fosforylace MeSH
- Jurkat buňky účinky léků MeSH
- kinasy ribozomálního proteinu S6, 70-kDa MeSH
- léky antitumorózní - screeningové testy MeSH
- leukocyty mononukleární účinky léků MeSH
- lidé MeSH
- molekulární struktura MeSH
- naftochinony krev chemická syntéza chemie izolace a purifikace farmakologie MeSH
- proliferace buněk účinky léků MeSH
- signální transdukce fyziologie MeSH
- TOR serin-threoninkinasy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 3-hexanoyl-2,5,7,8-tetrahydroxy-1,4-naphthoquinone MeSH Prohlížeč
- antitumorózní látky MeSH
- kinasy ribozomálního proteinu S6, 70-kDa MeSH
- MTOR protein, human MeSH Prohlížeč
- naftochinony MeSH
- TOR serin-threoninkinasy MeSH
Quambalarine B (QB) is a secondary metabolite produced by the basidiomycete Quambalaria cyanescens with potential anticancer activity. Here we report that QB at low micromolar concentration inhibits proliferation of several model leukemic cell lines (Jurkat, NALM6, and REH), whereas higher concentrations induce cell death. By contrast, the effect of QB on primary leukocytes (peripheral blood mononuclear cells) is significantly milder with lower toxicity and cytostatic activity. Moreover, QB inhibited expression of the C-MYC oncoprotein and mRNA expression of its target genes, LDHA, PKM2, and GLS. Finally, QB blocked the phosphorylation of P70S6K, a downstream effector kinase in mTOR signaling that regulates translation of C-MYC. This observation could explain the molecular mechanism behind the antiproliferative and cytotoxic effects of QB on leukemic cells. Altogether, our results establish QB as a promising molecule in anticancer treatment.
Citace poskytuje Crossref.org
