A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P<2 × 10(-3)). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk.

Academic Unit of Pathology Department of Neuroscience University of Sheffield Sheffield S10 2TN UK

Anatomical Pathology The Alfred Hospital Melbourne Victoria 3004 Australia

Biomedical Network on Rare Diseases 28029 Madrid Spain

Biomedical Sciences Institute Porto University Porto 4099 002 Portugal

Biostatistics and Informatics Shared Resource University of Kansas Medical Center Kansas City Kansas 66160 USA

Breakthrough Breast Cancer Research Centre The Institute of Cancer Research London SW3 6JB UK

Breast Cancer Research Unit Cancer Research Institute University Malaya Medical Centre 50603 Kuala Lumpur Malaysia

Cancer Center Kuopio University Hospital 70210 Kuopio Finland

Cancer Control and Population Sciences Duke Cancer Institute Durham North Carolina 27710 USA

Cancer Epidemiology Centre Cancer Council Victoria Melbourne Victoria 3004 Australia

Cancer Epidemiology Program Division of Population Sciences H Lee Moffitt Cancer Center and Research Institute Tampa Florida 33612 USA

Cancer Genetics Laboratory Peter MacCallum Cancer Centre Melbourne Victoria 3002 Australia

Cancer Pathology and Prevention Division of Cancer Prevention and Population Sciences Roswell Park Cancer Institute Elm and Carlton Streets Buffalo 14263 New York USA

Cancer Prevention and Control Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 USA

Cancer Prevention and Control Samuel Oschin Comprehensive Cancer Institute Cedars Sinai Medical Center Los Angeles California 90048 USA

Cancer Research Initiatives Foundation Sime Darby Medical Centre 47500 Subang Jaya Malaysia

Cancer Research Initiatives Foundation Subang Jaya 47500 Selangor Malaysia

Cancer Research Institute Seoul National University Seoul 08826 Korea

Cancer Research UK Clinical Trials Unit The Beatson West of Scotland Cancer Centre Glasgow G12 0YN UK

Cancer Risk and Prevention Clinic Dana Farber Cancer Institute Boston Massachusetts 02215 USA

Center for Clinical Cancer Genetics and Global Health University of Chicago Medical Center Chicago Illinois 60637 USA

Center for Genomic Medicine Rigshospitalet Copenhagen University Hospital 2100 Copenhagen Denmark

Center for Integrated Oncology University Hospital of Cologne 50676 Cologne Germany

Center for Medical Genetics Ghent University Ghent 9000 Belgium

Center for Medical Genetics NorthShore University Health System Evanston Illinois 60201 USA

Center for Molecular Medicine University Hospital of Cologne 50676 Cologne Germany

Center of Familial Breast and Ovarian Cancer University Hospital of Cologne 50676 Cologne Germany

Centre for Cancer Biomarkers Department of Clinical Science University of Bergen N 5020 Bergen Norway

Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria 3010 Australia

Centre for Epidemiology and Biostatistics University of Melbourne Melbourne Victoria 3010 Australia

Centre of Familial Breast and Ovarian Cancer Department of Gynaecology and Obstetrics and Centre for Integrated Oncology University Hospital of Cologne 50931 Cologne Germany

Centro de Investigación en Red de Enfermedades Raras Valencia 28029 Spain

Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts 02115 USA

Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology Carmel Medical Center and B Rappaport Faculty of Medicine Haifa 34362 Israel

Clinical Cancer Genetics for the City of Hope Clinical Cancer Genetics Community Research Network Duarte California 91010 USA

Clinical Genetics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Rockville Maryland 20892 USA

Community and Population Health Research Institute Department of Biomedical Sciences Cedars Sinai Medical Center Los Angeles California 90048 USA

Copenhagen General Population Study Herlev Hospital Copenhagen University Hospital Herlev 2730 Denmark

Department of Basic Sciences Shaukat Khanum Memorial Cancer Hospital and Research Centre Lahore 54000 Pakistan

Department of Biomedical Sciences Seoul National University College of Medicine Seoul 03080 Korea

Department of Breast Surgery Herlev Hospital Copenhagen University Hospital 2730 Herlev Denmark

Department of Cancer Epidemiology Clinical Cancer Registry University Medical Center Hamburg Eppendorf Hamburg 20246 Germany

Department of Cancer Epidemiology Moffitt Cancer Center Tampa Florida 33606 USA

Department of Cancer Prevention and Control Roswell Park Cancer Institute Buffalo New York 14263 USA

Department of Chronic Disease Epidemiology Yale School of Public Health New Haven Connecticut 06510 USA

Department of Clinical Biochemistry Herlev Hospital Copenhagen University Hospital Herlev 2730 Denmark

Department of Clinical Genetics Erasmus University Medical Center 3015 CE Rotterdam The Netherlands

Department of Clinical Genetics Fox Chase Cancer Center Philadelphia Pennsylvania 19111 USA

Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki 00029 HUS Finland

Department of Clinical Genetics Karolinska University Hospital 171 76 Stockholm Sweden

Department of Clinical Genetics Lund University Hospital Lund 221 00 Sweden

Department of Clinical Genetics Odense University Hospital 5000 Odense C Denmark

Department of Clinical Genetics Vejle Hospital Vejle 7100 Denmark

Department of Clinical Molecular Biology Oslo University Hospital University of Oslo 1478 Oslo Norway

Department of Community and Family Medicine Duke University Medical Center Durham North Carolina 27710 USA

Department of Community and Family Medicine Section of Biostatistics and Epidemiology The Geisel School of Medicine at Dartmouth Lebanon New Hampshire 03755 USA

Department of Dermatology Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City Utah 84132 USA

Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York 10017 USA

Department of Epidemiology Cancer Prevention Institute of California Fremont California 94538 USA

Department of Epidemiology Genetic Epidemiology Research Institute School of Medicine University of California Irvine Irvine California 92697 USA

Department of Epidemiology Harvard TH Chan School of Public Health Boston Massachusetts 02115 USA

Department of Epidemiology Mailman School of Public Health Columbia University New York 10027 USA

Department of Epidemiology University of Washington Seattle Washington 98109 USA

Department of Genetics and Pathology Pomeranian Medical University 70 204 Szczecin Poland

Department of Genetics and Pathology Pomeranian Medical University Szczecin 70 115 Poland

Department of Genetics Institute for Cancer Research Oslo University Hospital Radiumhospitalet Oslo N 0310 Norway

Department of Genetics Portuguese Oncology Institute Porto 4200 072 Portugal

Department of Genetics University of Pretoria Pretoria 0083 South Africa

Department of Gynaecology Radboud University Medical Centre 6500 Nijmegen The Netherlands

Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston Texas 77030 USA

Department of Gynecological Oncology Roswell Park Cancer Institute Buffalo New York 14263 USA

Department of Gynecology and Gynecologic Oncology Dr Horst Schmidt Kliniken Wiesbaden 65199 Wiesbaden Germany

Department of Gynecology and Gynecologic Oncology Kliniken Essen Mitte 45136 Essen Germany

Department of Gynecology and Obstetrics Haukeland University Hospital 5021 Bergen Norway

Department of Gynecology Family Cancer Clinic Erasmus MC Cancer Institute 3015 CE Rotterdam The Netherlands

Department of Gynecology Rigshospitalet University of Copenhagen 2100 Copenhagen Denmark

Department of Health Research and Policy Epidemiology Stanford University School of Medicine Stanford California 94305 USA

Department of Health Sciences Research Mayo Clinic Rochester Minnesota 55902 USA

Department of Human Genetics Leiden University Medical Center Leiden 2333 The Netherlands

Department of Human Genetics Radboud University Medical Centre 6500 Nijmegen The Netherlands

Department of Immunology Genetics and Pathology Uppsala University Uppsala 751 05 Sweden

Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario M5G 1L7 Canada

Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota 55905 USA

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm SE 171 77 Sweden

Department of Medical Oncology Beth Israel Deaconess Medical Center Boston Massachusetts 02215 USA

Department of Medical Oncology Family Cancer Clinic Erasmus MC Cancer Institute 3015 Rotterdam The Netherlands

Department of Medical Oncology The Center for Functional Cancer Epigenetics Dana Farber Cancer Institute Boston Massachusetts 02215 USA

Department of Medicine Abramson Cancer Center Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania 19104 USA

Department of Medicine and Genetics University of California San Francisco California 94143 USA

Department of Medicine Huntsman Cancer Institute University of Utah School of Medicine Salt Lake City Utah 84112 USA

Department of Medicine McGill University Montreal Québec H3A 1A1 Canada

Department of Medicine Memorial Sloan Kettering Cancer Center New York 10065 USA

Department of Molecular Genetics National Institute of Oncology 1122 Budapest Hungary

Department of Molecular Genetics University of Toronto Toronto Ontario M5S 1A8 Canada

Department of Molecular Medicine and Surgery Karolinska Institutet SE 171 77 Stockholm Sweden

Department of Molecular Virology Immunology and Medical Genetics The Ohio State University Columbus Ohio 43210 USA

Department of Obstetrics and Gynecology Comprehensive Cancer Center Medical University of Vienna 1090 Vienna Austria

Department of Obstetrics and Gynecology Duke University Medical Center Durham North Carolina 27710 USA

Department of Obstetrics and Gynecology Oregon Health and Science University Portland Oregon 97239 USA

Department of Obstetrics and Gynecology University of Heidelberg Heidelberg 69120 Germany

Department of Obstetrics and Gynecology University of Helsinki and Helsinki University Central Hospital Helsinki 00029 HUS Finland

Department of Oncology Centre for Cancer Genetic Epidemiology University of Cambridge Cambridge CB1 8RN UK

Department of Oncology Department of Public Health and Primary Care University of Cambridge Strangeways Research Laboratory Cambridge CB1 8RN UK

Department of Oncology Helsinki University Hospital University of Helsinki Helsinki FIN 00029 Finland

Department of Oncology Karolinska University Hospital Stockholm 171 77 Sweden

Department of Oncology Pathology Karolinska Institutet SE 171 77 Stockholm Sweden

Department of Oncology Rigshospitalet Copenhagen University Hospital 2100 Copenhagen Denmark

Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology Warsaw 44 101 Poland

Department of Pathology and Laboratory Medicine University of Kansas Medical Center Kansas City Kansas 66160 USA

Department of Pathology Helsinki University Central Hospital Helsinki 00029 Finland

Department of Pathology Landspitali University Hospital and BMC Faculty of Medicine University of Iceland Reykjavik 600169 2039 Iceland

Department of Pathology Leiden University Medical Center Leiden 2333 The Netherlands

Department of Pathology University of Melbourne Parkville Victoria 3010 Australia

Department of Population Sciences Beckman Research Institute of City of Hope Duarte California 91010 USA

Department of Preventive Medicine Keck School of Medicine University of Southern California Norris Comprehensive Cancer Center Los Angeles California 90033 USA

Department of Preventive Medicine Kyushu University Faculty of Medical Sciences Fukuoka 812 8582 Japan

Department of Preventive Medicine Seoul National University College of Medicine Seoul 08826 Korea

Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology University of Cambridge Cambridge CB1 8RN UK

Department of Surgery National University Health System Singapore 119077 Singapore

Department of Surgery Seoul National University College of Medicine Seoul 03080 Korea

Department of Surgery The University of Hong Kong Hong Kong China

Department of Surgery Tri Service General Hospital National Defense Medical Center Taipei 114 Taiwan

Department of Virus Lifestyle and Genes Danish Cancer Society Research Center DK 2100 Copenhagen Denmark

Division of Breast Cancer Research The Institute of Cancer Research London SW7 3RP UK

Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland 20892 USA

Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland 20892 USA

Division of Cancer Epidemiology German Cancer Research Center Heidelberg 69121 Germany

Division of Cancer Prevention and Genetics Istituto Europeo di Oncologia Milan 20141 Italy

Division of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg 69120 Germany

Division of Clinical Epidemiology Royal Victoria Hospital McGill University Montreal Québec H3A 1A1 Canada

Division of Clinical Genetics Department of Clinical and Experimental Medicine Linköping University 581 83 Linköping Sweden

Division of Epidemiology and Biostatistics Department of Internal Medicine University of New Mexico Albuquerque New Mexico 87131 USA

Division of Epidemiology and Prevention Aichi Cancer Center Research Institute Aichi 464 8681 Japan

Division of Epidemiology Dalla Lana School of Public Health University of Toronto Toronto Ontario M5T 3M7 Canada

Division of Epidemiology Department of Medicine Vanderbilt Ingram Cancer Center Vanderbilt University School of Medicine Nashville Tennessee 37203 USA

Division of Genetics and Epidemiology The Institute of Cancer Research London SW7 3RP UK

Division of Gynaecology and Obstetrics Technische Universität München 81675 Munich Germany

Division of Gynecologic Oncology NorthShore University HealthSystem Evanston Illinois 60201 USA

Division of Gynecological Oncology Department of Oncology University Hospitals Leuven B 3000 Leuven Belgium

Division of Health Sciences Warwick Medical School Warwick University Coventry CV4 7AL UK

Division of Molecular Gyneco Oncology Department of Gynaecology and Obstetrics University Hospital of Cologne 50676 Cologne Germany

Division of Preventive Oncology German Cancer Research Center Heidelberg 69121 Germany

Dr Margarete Fischer Bosch Institute of Clinical Pharmacology Stuttgart D 70376 Germany

Environmental Epidemiology of Cancer Center for Research in Epidemiology and Population Health INSERM 94805 Villejuif France

Faculty of Health and Medical Sciences University of Copenhagen Copenhagen 2200 Denmark

Family Cancer Clinic Netherlands Cancer Institute 1006 Amsterdam The Netherlands

Genetic Counseling Unit Hereditary Cancer Program IDIBGI Catalan Institute of Oncology Girona 08908 Spain

Genomic Medicine Manchester Academic Health Sciences Centre Institute of Human Development Manchester University Central Manchester University Hospitals NHS Foundation Trust Manchester M13 9PL UK

Genomics Center Centre Hospitalier Universitaire de Québec Research Center Laval University Québec City Québec G1V 4G2 Canada

German Cancer Consortium Heidelberg 69120 Germany

Gynaecology Research Unit Hannover Medical School Hannover D 30625 Germany

Gynecology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York 10065 USA

Harvard HT Chan School of Public Health Boston Massachusetts 02115 USA

Human Cancer Genetics Program Spanish National Cancer Research Centre Madrid E 28029 Spain

Human Genetics Group Human Cancer Genetics Program Spanish National Cancer Centre 28019 Madrid Spain

IFOM The FIRC Institute of Molecular Oncology 16 20139 Milan Italy

Imaging Center Department of Clinical Pathology Kuopio University Hospital 70210 Kuopio Finland

Immunology and Molecular Oncology Unit Instituto Oncologico Veneto IOV IRCCS 35128 Padua Italy

Immunology and Molecular Oncology Unit Istituto Oncologico Veneto IOV IRCCS 64 35128 Padua Italy

INSERM U1052 CNRS UMR5286 Université Lyon 1 Centre de Recherche en Cancérologie de Lyon Lyon 69003 France

INSERM U1052 CNRS UMR5286 Université Lyon Centre de Recherche en Cancérologie de Lyon Lyon 69373 France

Institut Curie Department of Tumour Biology Paris France; Institut Curie INSERM U830 75248 Paris France

Institute for Medical Biometrics and Epidemiology University Medical Center Hamburg Eppendorf Hamburg 20246 Germany

Institute for Medical Informatics Statistics and Epidemiology University of Leipzig 04107 Leipzig Germany

Institute of Cancer Sciences University of Glasgow Wolfson Wohl Cancer Research Centre Beatson Institute for Cancer Research Glasgow G61 1BD UK

Institute of Clinical Medicine Pathology and Forensic Medicine University of Eastern Finland 70210 Kuopio Finland

Institute of Human Genetics Department of Human Genetics University Hospital Heidelberg 69120 Heidelberg Germany

Institute of Human Genetics Pontificia Universidad Javeriana Cra 7 40 62 Bogota Colombia

Institute of Population Health University of Manchester Manchester M13 9PL UK

International Agency for Research on Cancer Lyon 69008 France

International Epidemiology Institute Rockville Maryland 20850 USA

K G Jebsen Center for Breast Cancer Research Institute of Clinical Medicine Faculty of Medicine University of Oslo Oslo N 0310 Norway

Knight Cancer Institute Oregon Health and Science University Portland Oregon 97239 USA

Laboratory for Translational Genetics Department of Oncology University of Leuven 3000 Leuven Belgium

Laboratory Medicine Program University Health Network Toronto Ontario M5G 1L7 Canada

Laboratory of Cancer Genetics and Tumour Biology Department of Clinical Chemistry and Biocenter Oulu University of Oulu FI 90014 Oulu Finland

Laboratory of Cancer Genetics and Tumour Biology Northern Finland Laboratory Centre NordLab FI 90014 Oulu Finland

Latvian Biomedical Research and Study Centre Riga LV 1067 Latvia

Lombardi Comprehensive Cancer Center Georgetown University Washington District of Columbia 20057 USA

Lunenfeld Tanenbaum Research Institute of Mount Sinai Hospital Toronto Ontario M5G 1X5 Canada

Masaryk Memorial Cancer Institute and Medical Faculty MU 625 00 Brno Czech Republic

Medical College Xiamen University Xiamen 361102 China

Molecular Diagnostic Unit Hereditary Cancer Program IDIBELL Catalan Institute of Oncology Barcelona 08908 Spain

Molecular Diagnostics Laboratory Institute of Nuclear and Radiological Sciences and Technology National Centre for Scientific Research 'Demokritos' Aghia Paraskevi Attikis Athens 153 10 Greece

Molecular Diagnostics Laboratory IRRP National Centre for Scientific Research 'Demokritos' Athens 153 10 Greece

Molecular Epidemiology Group German Cancer Research Center Heidelberg 69120 Germany

Molecular Genetics of Breast Cancer German Cancer Research Center Heidelberg 69120 Germany

Molecular Oncology Laboratory Hospital Clinico San Carlos IdISSC Madrid 28040 Spain

Molecular Unit Department of Pathology Herlev Hospital University of Copenhagen 2730 Copenhagen Denmark

Multidisciplinary Breast Center Department of General Medical Oncology University Hospitals Leuven B 3000 Leuven Belgium

N N Petrov Institute of Oncology St Petersburg 197758 Russia

National Cancer Institute Bangkok 10400 Thailand

National Center for Tumour Diseases University of Heidelberg 69117 Heidelberg Germany

Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital 1066 CX Amsterdam The Netherlands

Obstetrics and Gynecology Epidemiology Center Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts 02115 USA

Oncogenetics Group University Hospital Vall d'Hebron Vall d'Hebron Institute of Oncology and Universitat Autònoma de Barcelona Barcelona 08035 Spain

Program in Cancer Genetics Departments of Human Genetics and Oncology McGill University Montreal Montreal Quebec H2W 1S6 Canada

Program in Epidemiology Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington 98109 USA

Prosserman Centre for Health Research Lunenfeld Tanenbaum Research Institute of Mount Sinai Hospital Toronto Ontario M5G 1X5 Canada

QIMR Berghofer Medical Research Institute Brisbane Queensland 4029 Australia

Radboud University Medical Centre Radboud Institute for Health Sciences 6500 Nijmegen The Netherlands

Research Oncology Guy's Hospital King's College London London SE1 9RT UK

Saw Swee Hock School of Public Health National University of Singapore Singapore 119077 Singapore

School of Public Health China Medical University Taichung 404 Taiwan

Section of Genetic Oncology Department of Laboratory Medicine University and University Hospital of Pisa Pisa 56126 Italy

Shanghai Center for Disease Control and Prevention Shanghai China

Sheffield Cancer Research Department of Oncology University of Sheffield Sheffield S10 2TN UK

State Research Institute Centre for Innovative Medicine LT 01102 Vilnius Lithuania

Susanne Levy Gertner Oncogenetics Unit Sheba Medical Center Tel Hashomer 52621 Israel

Taiwan Biobank Institute of Biomedical Sciences Academia Sinica Taipei 115 Taiwan

The Hong Kong Hereditary Breast Cancer Family Registry Cancer Genetics Center Hong Kong Sanatorium and Hospital Hong Kong China

The Ohio State University and the James Cancer Center Columbus Ohio 43210 USA

The University of Texas School of Public Health Houston Texas 77030 USA

UCLA Schools of Medicine and Public Health Division of Cancer Prevention and Control Research Jonsson Comprehensive Cancer Center Los Angeles California 90024 USA

Unit of Medical Genetics Department of Preventive and Predictive Medicine Fondazione IRCCS 20133 Milan Italy

Unit of Molecular Bases of Genetic Risk and Genetic Testing Department of Preventive and Predictive Medicine Fondazione IRCCS 20133 Milan Italy

Unité de recherche en santé des populations Centre des maladies du sein Deschênes Fabia Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec Québec City Québec G1J 1Z4 Canada

Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents Hospices Civils de Lyon Centre Léon Bérard Lyon 69008 France

Université Paris Descartes Sorbonne Paris Cité 75270 Paris France

University Cancer Center Hamburg University Medical Center Hamburg Eppendorf Hamburg 20246 Germany

University Hospital Erlangen Department of Gynecology and Obstetrics Friedrich Alexander University Erlangen Nuremberg Comprehensive Cancer Center Erlangen EMN Erlangen 91054 Germany

University Malaya Cancer Research Institute Faculty of Medicine University Malaya Medical Centre University Malaya 59100 Kuala Lumpur Malaysia

University of California at Los Angeles David Geffen School of Medicine Department of Medicine Division of Hematology and Oncology Los Angeles California 90095 USA

University of Hawaii Cancer Center Honolulu Hawaii 96813 USA

University of Texas MD Anderson Cancer Center Houston Texas 77030 USA

University of Tübingen Tübingen 72074 Germany

University Paris Sud 91405 Villejuif France

UO Anatomia Patologica Ospedale di Circolo Università dell'Insubria 21100 Varese Italy

Vesalius Research Center VIB 3000 Leuven Belgium

Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre University of Oxford Oxford OX3 7BN UK

Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars Sinai Medical Center Los Angeles California 90048 USA

Women's Cancer UCL EGA Institute for Women's Health London WC1E 6AU UK

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Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes