The wet mechanochemical procedure for the capping of the CdS and CdS/ZnS quantum dot nanocrystals is reported. l-cysteine and polyvinylpyrrolidone (PVP) were used as capping agents. When using l-cysteine, the dissolution of cadmium(II) was almost none for CdS/ZnS nanocrystals. Moreover, prepared CdS- and CdS/ZnS-cysteine nanosuspensions exhibited unimodal particle size distributions with very good stability, which was further supported by the zeta potential measurements. The Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy showed the successful embedment of cysteine into the structure of the nanocrystals. Additionally, the optical properties were examined, and the results showed that the cysteine nanosuspension has promising fluorescence properties. On the other hand, PVP was not determined to be a very suitable capping agent for the present system. In this case, the release of cadmium(II) was higher in comparison to the l-cysteine capped samples. The nanosuspensions were successfully used for in vitro studies on selected cancer cell lines. Using fluorescence microscopy, it was evidenced that the nanocrystals enter the cell and that they can serve as imaging agents in biomedical applications.

Faculty of Medicine P J Šafárik University Trieda SNP 1 04011 Košice Slovakia

Faculty of Science P J Šafárik University Moyzesova 11 04001 Košice Slovakia

Faculty of Science P J Šafárik University Moyzesova 11 04001 Košice Slovakia; Biomedical Research Centre University Hospital Hradec Kralove Sokolska 581 50005 Hradec Kralove Czech Republic

Institute of Geotechnics Slovak Academy of Sciences Watsonova 45 04001 Košice Slovakia

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