Mixed epithelial and stromal tumor of the middle ear: The first case report
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články, práce podpořená grantem
PubMed
27746270
DOI
10.1016/j.humpath.2016.09.020
PII: S0046-8177(16)30244-1
Knihovny.cz E-zdroje
- Klíčová slova
- Corpus albicans like scar, Head and neck, Middle ear, Mixed epithelial and stromal tumor, Ovarian stroma,
- MeSH
- biopsie MeSH
- buňky stromatu chemie patologie MeSH
- diagnostické techniky molekulární MeSH
- epitelové buňky chemie patologie MeSH
- imunohistochemie MeSH
- lidé MeSH
- nádorové biomarkery analýza genetika MeSH
- nádory komplexní a smíšené chemie genetika patologie chirurgie MeSH
- nádory ucha chemie genetika patologie chirurgie MeSH
- počítačová rentgenová tomografie MeSH
- proliferace buněk MeSH
- senioři MeSH
- střední ucho chemie patologie chirurgie MeSH
- terminologie jako téma MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- nádorové biomarkery MeSH
We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces were lined by flat, cuboidal, or columnar epithelial cells, in most parts showing mucinous differentiation. The epithelial lining of the cysts strongly expressed cytokeratins AE1-3, CK7, CK8, CK18, CK19, EMA, and S100 protein. The stroma expressed CD34 and smooth muscle actin. No cytological atypia or mitoses were present, and the proliferative activity was less than 1% in both components. The clonality analysis proved the clonal nature of the neoplasm. We believe that this tumor is a new member in the family of neoplasms containing the OS, and therefore we propose the term mixed epithelial and stromal tumor of the middle ear.
Bioptical Laboratory Ltd Pilsen Czech Republic 32600
Department of Pathology Faculty of Medicine in Pilsen Charles University Prague Czech Republic 30460
Department of Radiology Faculty of Medicine in Pilsen Charles University Czech Republic 30460
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