The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.

1st University Department of Ophthalmology Aristotle University of Thessaloniki Thessaloniki Greece

Department of Pathology Democritus University of Thrace Alexandroupolis Greece

Eye Institute of Thrace Democritus University of Thrace Alexandroupolis Greece

Institut Carnot de Bourgogne University of Burgundy Bourgogne France

Institute of Vision and Optics University of Crete Heraklion Greece

Universidad de Alcalá Madrid Spain

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